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Erythropoietin Enhances Long-Term Neuroprotection and Neurogenesis in Neonatal Stroke

Gonzalez F.F.a, b · McQuillen P.a · Mu D.b, d · Chang Y.b, e · Wendland M.c · Vexler Z.b · Ferriero D.M.a, b

Author affiliations

Departments of aPediatrics, bNeurology, and cRadiology, University of California, San Francisco, Calif., USA; dDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China; eDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Corresponding Author

Fernando F. Gonzalez, MD

Departments of Neurology and Pediatrics, University of California, San Francisco

521 Parnassus Avenue, C215

San Francisco, CA 94143-0663 (USA)

Tel. +1 415 502 5822, Fax +1 415 502 5821, E-Mail gonzalezf@peds.ucsf.edu

Related Articles for ""

Dev Neurosci 2007;29:321–330

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Neonatal stroke leads to mortality and severe morbidity, but there is no effective treatment currently available. Erythropoietin (EPO) has been shown to promote cytoprotection and neurogenesis and decrease subventricular zone morphologic changes following brain injury. The long-term cellular response to EPO has not been defined, and local changes in cell fate decision may play a role in functional improvement. We performed middle cerebral artery occlusion in P10 rats. EPO treatment (5 U/g IP) significantly preserved hemispheric brain volume 6 weeks after injury. Furthermore, EPO increased the percentage of newly generated neurons while decreasing newly generated astrocytes following brain injury, without demonstrating long-term differences in the subventricular zone. These results suggest that EPO may neuroprotect and direct cell fate toward neurogenesis and away from gliogenesis in neonatal stroke.

© 2007 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Paper

Received: September 06, 2006
Accepted: July 10, 2006
Published online: August 31, 2007
Issue release date: August 2007

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

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