Pediatric Neurosurgery
Case Report
Cerebrospinal Fluid Penetration and Bacteriostatic Activity of Linezolid against Enterococcus faecalis in a Child with a Ventriculoperitoneal Shunt InfectionMilstone A.M.a · Dick J.b · Carson B.c · Siberry G.K.aaDivision of Pediatric Infectious Diseases, bDepartment of Pathology, cDivision of Pediatric Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Md., USA
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Pediatr Neurosurg 2007;43:406–409
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Article / Publication Details
First-Page Preview
Received: March 20, 2006
Accepted: August 16, 2006
Published online: September 07, 2007
Issue release date: September 2007
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1
ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)
For additional information: https://www.karger.com/PNE
Abstract
We report a 4-year-old girl with a complicated Enterococcus faecalis ventriculoperitoneal shunt infection who failed vancomycin therapy. We demonstrate linezolid’s high CSF penetration and its CSF bacteriostatic activity against E. faecalis. Linezolid may be a good alternative for treatment of ventriculoperitoneal shunt infections in cases of vancomycin-resistant organisms or apparent treatment failures.
© 2007 S. Karger AG, Basel
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Article / Publication Details
First-Page Preview
Received: March 20, 2006
Accepted: August 16, 2006
Published online: September 07, 2007
Issue release date: September 2007
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1
ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)
For additional information: https://www.karger.com/PNE
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