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Original Paper

Free Access

Effect of Rosuvastatin on Outcomes in Chronic Haemodialysis Patients: Baseline Data from the AURORA Study

Fellström B.a · Holdaas H.b · Jardine A.G.c · Rose H.d · Schmieder R.e · Wilpshaar W.f · Zannad F.g

Author affiliations

aDepartment of Medical Science, Renal Unit, University Hospital, Uppsala, Sweden; bDepartment of Nephrology, Rikshospitalet, University of Oslo, Oslo, Norway; cBHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow; dAstraZeneca, Macclesfield, UK; eDepartment of Nephrology and Hypertension, Universitätsklinik, Erlangen-Nürnberg, Erlangen, Germany; fformer AstraZeneca, Macclesfield, UK and gClinical Investigation Centre INSERM (CIC), Hôpital Jeanne d’Arc, Toul, France

Corresponding Author

Professor Bengt Fellström

Department of Medical Science, Renal Unit, University Hospital

SE–751 85 Uppsala (Sweden)

Tel. +46 18 611 0000, ext. 4348, Fax +46 18 38304

E-Mail bengt.fellstrom@medsci.uu.se

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Background: Cardiovascular disease (CVD) is the leading cause of death in patients with end-stage renal disease (ESRD). Aims: AURORA (A study to evaluate the Use of Rosuvastatin in subjects On Regular haemodialysis: an Assessment of survival and cardiovascular events) is the first large-scale international trial to assess the effects of statins on cardiovascular outcomes in patients with ESRD on chronic haemodialysis. Preliminary baseline data from the randomised population are presented. Methods: A total of 2,775 patients from 280 centres in 25 countries were randomised into the study. Patients aged 50–80 years on regular chronic haemodialysis for at least 3 months before screening were eligible for inclusion. They were randomised 1:1 to receive either rosuvastatin 10 mg or placebo daily and assessed throughout the study. Results: The mean age at baseline was 64 years. Most patients were male (62%) and 85% were white. The median time since commencing renal replacement was 32 months. Mean total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were 4.53 mmol/l (175 mg/dl) and 2.57 mmol/l (99 mg/dl), respectively. Conclusion: Results from the AURORA trial will impact on the current guidelines and use of statins in this patient population.

© 2007 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 26, 2007
Accepted: May 11, 2007
Published online: July 31, 2007
Issue release date: September 2007

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 5

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

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