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Original Research Article

Effect of Phosphatidylserine on Cerebral Glucose Metabolism in Alzheimer's Disease

(With 1 color plate)
Klinkhammer P. · Szelies B. · Heiss W.-D.

Author affiliations

Klinik und Poliklinik für Neurologie und Psychiatrie der Universität zu Köln, FRG

Related Articles for ""

Dement Geriatr Cogn Disord 1990;1:197–201

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: January 31, 1991
Issue release date: 1990

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

In a preliminary study of 8 patients with probable Alzheimer''s disease (AD), the effect of phosphatidyl-serine (PS; 500 mg daily for 3 weeks) on brain glucose metabolism was studied using positron emission tomography (PET) of fluor-18-deoxyglucose. In all cases, pretreatment PET studies showed the metabolic pattern typical for AD, with predominant decreases in the parieto-occipito-temporal and frontal association cortex and less involvement of primary cortical areas and subcortical structures. Global metabolic rate increased by 14.8% following treatment. A repeated-measures ANOVA demonstrated significant increases (p < 0.01) of glucose metabolism in defined cortical and subcortical structures ranging up to 20.3% in basal ganglia/thalamus and 19.3% in visual cortex. Metabolism was also increased in areas most involved in AD (13.5–16%). Independent from these regional differences, an inverse correlation was observed between metabolic values and changes during the treatment period. A significant change of MMS scores or daily life activity, however, could not be observed during the 3 weeks of treatment. This shown metabolic effect of PS encourages long-term clinical trials on larger patient populations in which the effect of an increment of glucose metabolism on cognitive, neuropsychological and daily life performance can be additionally evaluated.

© 1990 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: January 31, 1991
Issue release date: 1990

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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