Use of Electroacupuncture at ST36 to Inhibit Anaphylactic and Inflammatory Reaction in MiceMoon P.-D.a, d · Jeong H.-J.a, d · Kim S.-J.a, d · An H.-J.a · Lee H.-J.b · Yang W.M.c · Park S.K.c · Hong S.-H.d · Kim H.-M.a · Um J.-Y.a, b
aDepartment of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, bAcupuncture and Meridian Science Research Center, cDepartment of Prescriptionology, College of Oriental Medicine, Kyung Hee University, Seoul, and dCollege of Pharmacy, Wonkwang University, Jeonbuk, Republic of Korea
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Objective: Electroacupuncture (EA) has been used to treat myalgia, allergy and gastroenteropathy in Korea. To determine whether EA can treat anaphylactic and inflammatory reactions, the effect of EA was investigated in a murine model. Methods: EA stimulation of the ST36 acupoint was performed for 10 min. Using a passive cutaneous anaphylaxis (PCA) model, the antianaphylactic effects of EA were examined. Interleukin-6 and tumor necrosis factor-α were measured using the ELISA method. The level of nuclear factor (NF)-ĸB/RelA protein and NF-ĸB DNA-binding activity was determined using the Western blot analysis and the transcription factor enzyme-linked immunoassay method. Results: EA inhibits PCA and β-hexosaminidase release, IL-6 secretion on the PCA, and in addition, EA reduces NF-ĸB DNA-binding activity. Conclusion: These results indicate that EA may possess antianaphylactic and antiinflammatory properties.
© 2007 S. Karger AG, Basel
- Kumar AM, Wen XL: Acupuncture treatment for osteoarthritic pain and inflammation of the knee. Altern Ther Health Med 2002;8:128.
- Zijlstra FJ, van den Berg-de Lange I, Huygen FJ, Klein J: Antiinflammatory actions of acupuncture. Mediators Inflamm 2003;12:59–69.
- Liao YY, Seto K, Saito H, Fujita M, Kawakami M: Effect of acupuncture on adrenocortical hormone production. 1. Variation in the ability for adrenocortical hormone production in relation to the duration of acupuncture stimulation. Am J Chin Med 1979;7:362–371.
- Liao YY, Seto K, Saitoh H, Kawakami M: Effect of acupuncture on adrenocortical hormone production in rabbits with a central lesion. Am J Chin Med 1981;9:61–73.
- Kimura A, Sato A: Somatic regulation of autonomic functions in anesthetized animals – neural mechanisms of physical therapy including acupuncture. Jpn J Vet Res 1997;45:137–145.
- Mori H, Uchida S, Ohsawa H, Noguchi E, Kimura T, Nishijo K: Electro-acupuncture stimulation to a hindpaw and a hind leg produces different reflex responses in sympathoadrenal medullary function in anesthetized rats. J Auton Nerv Syst 2000;79:93–98.
- Woiciechowsky C, Schoning B, Lanksch WR, Volk HD, Docke WD: Mechanisms of brain-mediated systemic anti-inflammatory syndrome causing immunodepression. J Mol Med 1999;77:769–780.
- Miescher SM, Vogel M: Molecular aspects of allergy. Mol Aspects Med 2002;23:413–462.
- Emi M, Maeyama K: The biphasic effects of cyclopentenone prostaglandins, prostaglandin J(2) and 15-deoxy-delta(12,14)-prostaglandin J(2) on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells. Biochem Pharmacol 2004;67:1259–1267.
Bazin H, Barta O, Barta VD: Hypersensibilité de type I; in Pastoret P, Govaerts A, Bazin H (eds): Immunologie Animale. Paris, Flammarion, 1990, p 313.
- Verdier F, Chazal I, Descotes J: Anaphylaxis models in the guinea-pig. Toxicology 1994;93:55–61.
- Royer B, Varadaradjalou S, Saas P, Gabiot AC, Kantelip B, Feger F, Guillosson JJ, Kantelip JP, Arock M: Autocrine regulation of cord blood-derived human mast cell activation by IL-10. J Allergy Clin Immunol 2001;108:80–86.
- Stassen M, Müller C, Arnold M, Hultner L, Klein-Hessling S, Neudorfl C, Reineke T, Serfling E, Schmitt E: IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-κB is decisively involved in the expression of IL-9. J Immunol 2001;166:4391–4398.
- Petersen LJ, Mosbech H, Skov PS: Allergen-induced histamine release in intact human skin in vivo assessed by skin microdialysis technique: characterization of factors influencing histamine releasability. J Allergy Clin Immunol 1996;97:672–679.
- Moon PD, Choi IY, Na HJ, Jeong HJ, Kim CH, Kim HR, Kim YK, Park SK, Hong SH, Kim HM: Rubus croceacanthus Leveille inhibits mast cell-mediated anaphylactic-like reaction and tumor necrosis factor-α secretion. Biol Pharm Bull 2004;27:1359–1363.
- Moon PD, Na HJ, Jeong HJ, Hong SH, Kim SJ, Chae HJ, Kim HR, Choi JO, Lee SH, Shin JY, Kim HM: Inhibitory effect of Gamibojungikgitang extract on mast cell-mediated allergic reaction in murine model. J Pharm Pharm Sci 2005;8:94–101.
- Conti P, Kempuraj D, Di Gioacchino M, Boucher W, Letourneau R, Kandere K, Barbacane RC, Reale M, Felaco M, Frydas S, Theoharides TC: Interleukin-6 and mast cells. Allergy Asthma Proc 2002;23:331–335.
- Kikuchi T, Ishida S, Kinoshita T, Sakuma S, Sugawara N, Yamashita T, Koike K: IL-6 enhances IgE-dependent histamine release from human peripheral blood-derived cultured mast cells. Cytokine 2002;20:200–209.
- Iwasaki M, Saito K, Takemura M, Sekikawa K, Fujii H, Yamada Y, Wada H, Mizuta K, Seishima M, Ito Y: TNF-α contributes to the development of allergic rhinitis in mice. J Allergy Clin Immunol 2003;112:134–140.
- van Houwelingen AH, Kool M, de Jager SC, Redegeld FA, van Heuven-Nolsen D, Kraneveld AD, Nijkamp FP: Mast cell-derived TNF-α primes sensory nerve endings in a pulmonary hypersensitivity reaction. J Immunol 2002;168:5297–5302.
- Barnes PJ, Karin M: Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066–1071.
- Baeuerie PA, Henkel T: Function and activation of NF-κB in the immune system. Annu Rev Immunol 1994;12:141–179.
- Siebenlist U, Franzoso G, Brown K: Structure, regulation and function of NF-κB. Annu Rev Cell Biol 1994;10:405–455.
- Kuprsh DV, Udalova IA, Turetskaya RL, Rice NR, Nedospasov SAC: Conserved κB element located downstream of the tumor necrosis factor-α gene: distinct NF-κB binding pattern and enhancer activity in LPS activated murine macrophages. Oncogene 1995;11:97–106.
- Galien R, Evans HF, Garcia T: Involvement of CCAAT/enhancer-binding protein and nuclear factor-κB binding site in interleukin-6 promoter inhibition by estrogens. Mol Endocrinol 1996;10:713–722.
- Beg AA, Finco TS, Nantermet PV, Baldwin AS Jr: Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκB: a mechanism for NF-κB activation. Mol Cell Biol 1993;13:3301–3310.
- Palombella V, Rando O, Goldberg A, Maniatis T: The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 1994;78:773–785.
- Park MB, Ko E, Ahn C, Choi H, Rho S, Shin MK, Hong MC, Min BI, Bae H: Suppression of IgE production and modulation of Th1/Th2 cell response by electroacupuncture in DNP-KLH immunized mice. J Neuroimmunol 2004;151:40–44.
- Park IB, Ahn CB, Choi BT: Effects of electroacupuncture with different frequencies on the glycoconjugate alterations in articular cartilage in the ankle joints of complete Freund’s adjuvant-injected rats. Am J Chin Med 2006;34:417–426.
- Katayama S, Shionoya H, Ohtake S: A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous allergy in guinea pigs and rats. Microbiol Immunol 1978;22:89–101.
- Kim HM, Lee YM: Role of TGF-β1 on the IgE-dependent anaphylaxis reaction. J Immunol 1999;162:4960–4965.
- Moon PD, Lee BH, Jeong HJ, An HJ, Park SJ, Kim HR, Ko SG, Um JY, Hong SH, Kim HM: Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the IκB/NF-κB signal cascade in the human mast cell line HMC-1. Eur J Pharmacol 2007;555:218–225.
- Shin HY, Na HJ, Moon PD, Shin T, Shin TY, Kim SH, Hong SH, Kim HM: Inhibition of mast cell-dependent immediate-type hypersensitivity reactions by purple bamboo salt. J Ethnopharmacol 2004;91:153–157.
- Wershil BK, Mekori YA, Murakami T, Galli SJ: 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells. J Immunol 1987;139:2605–2614.
Mousli MC, Bronner C, Landry Y, Bockaert J, Rouot B: Direct activation of GTP-binding regulatory proteins (G proteins) by substance P and compound 48/80. FEBS Lett 1990;25:260–262.
- Mousli MC, Bronner C, Bockaert J, Rouot B, Landry Y: Interaction of substance P, compound 48/80 and mastoparan with α-subunit C-terminal of G protein. Immunol Lett 1990;25:355–358.
- Chadi A, Fraundorfer PF, Beaven MA: Compound 48/80 activates mast cell phospholipase D via heterotrimeric GTP-binding proteins. J Pharmacol Exp Ther 2000;292:122–130.
- Alfonso A, Cabado AG, Vieytes MR, Botana LM: Functional compartments in rat mast cells for cAMP and calcium on histamine release. Cell Signal 2000;12:343–350.
Tasaka K, Mio M, Okamoto M: Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann Allergy Asthma Immunol 1986;56:464–469.
- Daeron M: Fc receptor biology. Annu Rev Immunol 1997;15:203–234.
- Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M: Mast cells as ‘tunable’ effector and immunoregulatory cells: recent advances. Annu Rev Immunol 2005;23:749–786.
- Galli SJ, Nakae S, Tsai M: Mast cells in the development of adaptive immune responses. Nat Immunol 2005;6:135–142.
- Kitamura K, Nakamoto Y, Kaneko S, Mukaida N: Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis. J Leukoc Biol 2004;76:1111–1117.
- Lamprecht P: TNF-α inhibitors in systemic vasculitides and connective tissue diseases. Autoimmun Rev 2005;4:28–34.
- Rao A: NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. Immunol Today 1994;15:274–281.
- Fiorini E, Marchisio PC, Scupoli MT, Poffe O, Tagliabue E, Brentegani M, Colombatti M, Santini F, Tridente G, Ramarli D: Adhesion of immature and mature T cells induces in human thymic epithelial cells (TEC) activation of IL-6 gene trascription factors (NF-κB and NF-IL6) and IL-6 gene expression: role of α3β1 and α6β4 integrins. Dev Immunol 2000;7:195–208.
- Jeong HJ, Koo HN, Na HJ, Kim MS, Hong SH, Eom JW, Kim KS, Shin TY, Kim HM: Inhibition of TNF-α and IL-6 production by aucubin through blockade of NF-κB activation RBL-2H3 mast cells. Cytokine 2002;18:252–259.
- Collart MA, Baeuerle P, Vassaili P: Regulation of tumor necrosis factor-α transcription in macrophages: involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB. Mol Cell Biol 1990;10:1498–1506.
- MacDermott RP, Schloemann SR, Berotvich MJ, Nash GS, Peters M, Stenson WF: Inhibition of antibody secretion by 5-aminosalicylic acid. Gastroenterology 1989;96:442–448.
- Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr: Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 1995;270:283–286.
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