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Original Paper

Improving Proteinuria, Endothelial Functions and Asymmetric Dimethylarginine Levels in Chronic Kidney Disease: Ramipril versus Valsartan

Yilmaz M.I.a, f · Saglam M.b · Sonmez A.c · Caglar K.a · Cakir E.d · Kurt Y.d · Eyileten T.a · Tasar M.b · Acikel C.e · Oguz Y.a · Vural A.a · Yenicesu M.a

Author affiliations

Departments of aNephrology, bRadiology, cInternal Medicine, dBiochemistry, and eEpidemiology, Gülhane School of Medicine, Etlik-Ankara, Turkey; fDivisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden

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Blood Purif 2007;25:327–335

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 23, 2007
Accepted: May 18, 2007
Published online: August 20, 2007
Issue release date: September 2007

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 5

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: https://www.karger.com/BPU

Abstract

Background: The aim of this study was to find out whether the beneficial effects of the renin-angiotensin-aldosterone system (RAS) blockage in chronic kidney disease (CKD) has any relation with the alteration of asymmetric dimethylarginine (ADMA) levels. Methods: Sixty-six nondiabetic patients with CKD and proteinuria and 36 healthy subjects were enrolled. Patients were treated with either ramipril 5 mg daily or valsartan 160 mg daily for 3 months. Proteinuria, ADMA, symmetric dimethyl arginine (SDMA), flow-mediated dilatation (FMD) and HOMA index measurements were performed both before and after the treatment. Results: ADMA, SDMA, hsCRP levels, HOMA index and proteinuria of patients were significantly higher (p < 0.001 for all) and FMD, L-arginine and L-arginine/ADMA ratio in CKD were significantly lower than controls. According to the multiple regression analysis, proteinuria levels were independently related to ADMA and SDMA levels. Conclusion: Both drugs were equally effective in reducing elevated ADMA levels and improving endothelial dysfunction in CKD patients.

© 2007 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 23, 2007
Accepted: May 18, 2007
Published online: August 20, 2007
Issue release date: September 2007

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 5

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: https://www.karger.com/BPU


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