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Original Paper

Exaggerated Beat-to-Beat R Amplitude Variability in Patients with Panic Disorder after Intravenous Isoproterenol

Yeragani V.K.a-c · Pohl R.a · Bär K.-J.d · Chokka P.b · Tancer M.a

Author affiliations

aDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Mich., USA; bDepartment of Psychiatry, University of Alberta, Edmonton, Alb., Canada; cDepartment of Cardiology, M.S. Ramaiah Memorial Hospital, Bangalore, India; dDepartment of Psychiatry, Friedrich Schiller University, Jena, Germany

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Neuropsychobiology 2007;55:213–218

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 22, 2007
Accepted: April 07, 2007
Published online: September 17, 2007
Issue release date: October 2007

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Background: Anxiety symptoms are associated with a marked increase in sudden cardiac death, suggesting an abnormality in cardiac autonomic function. Our previous studies show a relationship between R amplitude variability and sympathetic function.Methods:We examined the effects of β-adrenergic stimulation on R and T amplitude variability in panic disorder patients by infusing the β-adrenergic agonist isoproterenol in 6 panic disorder patients and 11 normal subjects. The ECG signal was analyzed before the infusion and 5 min after the infusion was started. The outcome measures were the R and T detrended variance normalized for mean amplitudes (Rvm and Tvm) and the Rvi and Tvi, measures which are normalized for the inter-beat interval variability in addition. Results: Patients with panic disorder had significantly more variability in R and T amplitude than normal controls and the R amplitude variability was increased further by β-adrenergic stimulation with isoproterenol, which was more pronounced in the patients. Conclusions: The isoproterenol-associated increase in R amplitude variability occurred in controls in the absence of significant anxiety. However, the increase in R amplitude variability was greater in patients with panic disorder, suggesting a greater sensitivity to β-adrenergic effects of isoproterenol or to isoproterenol-induced anxiety.

© 2007 S. Karger AG, Basel


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    External Resources
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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 22, 2007
Accepted: April 07, 2007
Published online: September 17, 2007
Issue release date: October 2007

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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