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Cognitive Impairment in Parkinson’s Disease and Dementia with Lewy Bodies: A Spectrum of Disease

Goldmann Gross R. · Siderowf A. · Hurtig H.I.

Author affiliations

Parkinson’s Disease and Movement Disorders Center, Department of Neurology, University of Pennsylvania Health System, Philadelphia, Pa., USA

Corresponding Author

Andrew Siderowf, MD, MSCE

Department of Neurology, University of Pennsylvania School of Medicine

330 South 9th Street

Philadelphia, PA 19107 (USA)

Tel. +1 215 829 6500, Fax +1 215 829 6606, E-Mail siderow@pahosp.com

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Neurosignals 2008;16:24–34

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Parkinson’s disease (PD) is classically thought of as a movement disorder characterized by tremor, rigidity and postural instability. Nevertheless, there is growing recognition of prominent cognitive impairment in PD and related disorders, which is responsible for substantial disability in these patients. This review will focus on cognitive impairment associated with Lewy body pathology, including PD with dementia (PDD) and dementia with Lewy bodies (DLB). We will review the epidemiology, clinical evaluation, underlying mechanisms and treatment of cognitive impairment in these patients. Despite differences between PDD and DLB, there is clinical, neuropathological and radiological overlap between these disorders, supporting the view that they represent a spectrum of disease. These observations suggest that common targets for diagnosis and treatment of these disorders can be identified.

© 2008 S. Karger AG, Basel


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Article / Publication Details

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Published online: December 05, 2007
Issue release date: December 2007

Number of Print Pages: 11
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Number of Tables: 4

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

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