Neuroepidemiology

Original Papers

Long-Term Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the Peripheral Nervous System

Clinical and Neurophysiological Controlled Study on Subjects with Chloracne from the Seveso Area
Barbieri S.a · Pirovano C.a · Scarlato G.a · Tarchini P.b · Zappa A.b · Maranzana M.b

Author affiliations

a Istituto Clinica Neurologica e Centro ‘Dino Ferrari’, University of Milan, and b Centro di Teoria dei Sistemi, CNR, Dipartimento di Elettronica, Politecnico di Milano, Milan, Italy

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Neuroepidemiology 1988;7:29–37

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Article / Publication Details

First-Page Preview
Abstract of Original Papers

Published online: December 10, 1987
Issue release date: 1988

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: https://www.karger.com/NED

Abstract

This work was set up to investigate the possible presence of peripheral nervous system involvement as a long-term effect of the exposure to dioxin in 152 subjects with chloracne from the Seveso area; 123 age- and sex-matched subjects living in nearby towns with similar environmental pollution formed the control group. The accident in Seveso took place in July, 1976, and this study was carried out from October, 1982, to May, 1983. Although a peripheral neuropathy was not found in any of the subjects, a significant increase of the number of individuals presenting at least two bilateral clinical signs (p < 0.05) or one abnormal electrophysiological parameter (p < 0.02) was found in the Seveso group. Principal component analysis did not show any subdivision between these two groups. The Fisher approach to discriminant analysis reveals a clear subdivision between the group of the most exposed subjects and randomly selected subgroups of control subjects. In conclusion, clinical and electrophysiological signs of peripheral nervous system involvement occur with a statistically increased frequency in the Seveso population 6 years after the accident, although a peripheral neuropathy was not evident in any of the chloracne patients using the World Health Organization diagnostic criteria.

© 1988 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Papers

Published online: December 10, 1987
Issue release date: 1988

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: https://www.karger.com/NED


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