Neuroepidemiology
Original Papers
Genetic Analysis of Late-Onset Diseases Using First-Degree RelativesSobel E. · Davanipour Z. · Alter M.Neuroepidemiology Section, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA
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Article / Publication Details
Published online: April 06, 1988
Issue release date: 1988
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)
For additional information: https://www.karger.com/NED
Abstract
We consider the problem of testing that a disease with variable age at onset is an autosomal dominant or recessive genetic trait. Specific reference is made to Alzheimer’s disease and recent publications proposing an autosomal dominant inheritance pattern. The pedigree structure allowed is restricted to first-degree relatives of the proband for the dominant and to sibs of the proband for the recessive hypotheses, respectively, in addition to the proband. The sampling method assumed is the one most often used in practice: single ascertainment or sampling pedigrees with probability proportional to size (pps), i.e., to the number of affected individuals within a pedigree who are in the sampling frame. The statistical methodology developed takes the sampling procedure into account and is a generalization of the Kaplan-Meier method of estimating survival functions to pps sampling.
© 1988 S. Karger AG, Basel
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Article / Publication Details
Published online: April 06, 1988
Issue release date: 1988
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)
For additional information: https://www.karger.com/NED
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