Original Research Article
Neuropsychiatric Syndromes in Dementia
Results from the European Alzheimer Disease Consortium: Part IAalten P.a · Verhey F.R.J.a · Boziki M.b · Bullock R.c · Byrne E.J.d · Camus V.f · Caputo M.i · Collins D.d · De Deyn P.P.m · Elina K.b · Frisoni G.j · Girtler N.k · Holmes C.e · Hurt C.d · Marriott A.c · Mecocci P.i · Nobili F.k · Ousset P.J.g · Reynish E.g · Salmon E.l · Tsolaki M.b · Vellas B.g · Robert P.H.h
aDepartment of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands; bDepartment of Neurology, Thessaloniki, Greece; cKingshill Research Centre, Victoria Hospital, Swindon, dDivision of Psychiatry, University of Manchester, Education and Research Centre, Wythenshawe Hospital, Manchester, and eClinical Neurosciences Research Division, Memory Assessment and Research Centre, University of Southampton, Southampton, UK; fClinique Psychiatrique Universitaire, CRU de Tours et Université François Rabelais, Tours, gDepartment of Internal and Geriatrics Medicine, Hôpitaux de Toulouse, Toulouse, and hCentre Mémoire de Ressources et de Recherche, CHU, Hôpital Pasteur, Université de Nice-Sophia Antipolis, Nice, France; iInstitute of Gerontology and Geriatrics, University of Perugia, Perugia, jNational Centre for Research and Care of Alzheimer’s and Mental Diseases, Brescia, and kClinical Neurophysiology Service, Department of Internal Medicine, University of Genoa, Genoa, Italy; lUniversity of Liège, Cyclotron Research Centre, and CHU Liège, Memory Centre, Liège, and mDepartment of Neurology, ZNA and Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
Dr. P. Aalten
Department of Psychiatry and Neuropsychology, Maastricht University Hospital
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NL–6202 AZ Maastricht (The Netherlands)
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Background/Aims: The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer’s disease (AD). Methods: Cross-sectional data of 2,354 patients with AD from 12 centres from the European Alzheimer’s Disease Consortium were collected. Principal component analysis was used for factor analysis. Results: The results showed the presence of 4 neuropsychiatric subsyndromes: hyperactivity, psychosis, affective symptoms and apathy. The subsyndrome apathy was the most common, occurring in almost 65% of the patients. Conclusion: This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD.
© 2007 S. Karger AG, Basel
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