Dementia and Geriatric Cognitive Disorders

Original Research Article

Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment

Rozzini L.a, b · Vicini Chilovi B.a, b · Conti M.a · Delrio I.a · Borroni B.a · Trabucchi M.b · Padovani A.a

Author affiliations

aNeurological Clinic, University of Brescia, and bGeriatric Research Group, Brescia, Italy

Keywords: Behavioral disordersBehavioral/psychological symptoms in dementiaMild cognitive impairment

Related Articles for ""
Dement Geriatr Cogn Disord 2008;25:32–36
https://doi.org/10.1159/000111133

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: May 09, 2007
Published online: November 19, 2007
Issue release date: December 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Background: The information regarding neuropsychiatric symptoms in the subtypes of mild cognitive impairment (MCI) is inadequate. Objective: To describe the behavioral neuropsychiatric symptoms of MCI in two subgroups of MCI patients with different neuropsychological characteristics. Methods: MCI patients are classified as amnestic (aMCI) if they have a prominent memory impairment, either alone or with other cognitive impairments (multiple domains with amnesia), or nonamnestic (naMCI) if a single nonmemory domain is impaired alone or in combination with other nonmemory deficits (multiple domains without amnesia). The Neuropsychiatric Inventory (NPI) was administrated to detect behavioral and psychological disturbances observed by the caregiver. Results: 120 subjects were analyzed: 94 were classified as aMCI and 26 as naMCI. Subjects with aMCI were more compromised than those with naMCI on global cognitive functions. About 85% of MCI patients had some neuropsychiatric symptoms evaluated with the NPI and the most prevalent symptom was depression, followed by anxiety. A significantly higher prevalence of hallucinations and sleep disorders has been observed in the naMCI group in comparison with the aMCI group. Conclusion: Neuropsychiatric symptoms occur in the majority of persons with MCI and may be the earliest manifestation of different diseases, each one associated with different clinical profiles at the stage of MCI.

© 2007 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: May 09, 2007
Published online: November 19, 2007
Issue release date: December 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

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2008, Vol.25, No. 1

December 2007

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