Higher Content of C18:1 Trans Fatty Acids in Early Human Milk Fat of Roma Breast-Feeding WomenMarhol P.a · Dlouhý P.b · Rambousková J.b · Pokorný R.c · Wiererová O.c · Hrnčířová D.b · Procházka B.b · Anděl M.b
aLaboratory of Biotransformation, National Centre of Biocatalysis and Biotransformation, Academy of Sciences of the Czech Republic; bCentre for Research of Diabetes, Metabolism and Nutrition, 3rd Faculty of Medicine, Charles University, and cDepartment of Gynaecology and Obstetrics, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
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Aim: The purpose of our study was to determine the content of trans fatty acids in early human breast milk as an indicator of dietary exposure in a sample of Roma breast-feeding women and in a sample of women from the general Czech population. Methods: We collected samples of early human milk from 43 Prague women from the general population and 21 Roma women. After lipid extraction, the fatty acids were converted into methyl esters (FAMEs). Finally, gas chromatography with flame ionization detector (GC-FID) analysis on a CP-Sil 88 column was used to determine C18:1 trans monoenic fatty acid levels and total trans isomers fatty acid levels in human milk. Results: A significantly higher content of C18:1 trans fatty acid isomers was detected in human milk fat from Roma mothers than in women of the general population (2.73 vs. 2.09%, p < 0.05). Both groups monitored did not differ in the representation of total fatty acid trans isomers. Differences in the frequency of consumption of certain TFA sources (butter, fried crisps) were established. Conclusions: The study proved a higher fatty acid trans isomers content in Roma breast-feeding mothers in the Czech Republic, and this is probably related to their bad eating habits.
© 2007 S. Karger AG, Basel
- Willett WC, Stampfer MJ, Manson JE, Colditz GA, Speizer FE, Rosner BA, et al: Intake of trans fatty acids and risk of coronary heart disease among women. Lancet 1993;341:581–585.
Kris-Etherton PM, Allison DB, Denke MA, Dietschy JM, Emken EA, Nicolosi RJ: Trans fatty acids and coronary heart disease risk. Report of the expert panel on trans fatty acids and coronary heart disease. Am J Clin Nutr 1995;62:655S–708S.
- Oh K, Hu FB, Manson JE, Stampfer MJ, Willett WC: Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the Nurses Health Study. Am J Epidemiol 2005;161:672–679.
- Willett WC: Trans fatty acids and cardiovascular disease – epidemiological data. Atheroscler Suppl 2006;7:5–8.
- Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC: Trans fatty acids and cardiovascular disease. N Engl J Med 2006;354:1601–1613.
- Mensink RP, Zock PL, Kester AD, Katan MB: Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77:1146–1155.
- Christiansen E, Schnider S, Palmvig B, Tauber-Lassen E, Pedersen O: Intake of diet in high transmonosaturated fatty acids or saturated fatty acids: effects on postprandial insulinemia and glycemia in obese patiens with NIDDM. Diabetes Care 1997;20:881–887.
- Hu FB, Van Dam RM, Liu S: Diet and risk of type 2 diabetes: the role of types of fat and carbohydrate. Diabetologia 2001;44:805–817.
- Riserus U: Trans fatty acids and insulin resistance. Atheroscler Suppl 2006;7:37–39.
- Koletzko B: Trans fatty acids may impair biosynthesis of long-chain polyunsaturates and growth in man. Acta Paediatr 1992;81:302–306.
- Decsi T, Koletzko B: Do trans fatty acids impair linoleic acid metabolism in children? Ann Nutr Metab 1995;39:36–41.
Dostálová J, Pokorný J: Dietary intake of fatty acids in the Czech Republic (in Czech); in Sborník z XL Mezinárodní Konference z Technologie a Analytiky Tuků, Harrachov-Rýžoviště, 2002, pp 14–19.
Dlouhý P, Pokorný J, Dostálová J: Dietary intake of trans unsaturated isomers of fatty acids in the Czech Republic (in Czech). DMEV 2004;7:136–138.
- Dlouhý P, Tvrzická E, Staňková B, Buchtíková M, Pokorný R, Wiererová O, Bílková D, Rambousková J, Anděl M: Trans fatty acids in subcutaneous fat of pregnant women and in human milk in the Czech Republic. Ann NY Acad Sci 2002;967:544–547.
- Dlouhý P, Tvrzická E, Staňková B, Vecka M, Žák A, Fanta J, Pachl J, Kubisová D, Rambousková J, Bílková D, Anděl M: Higher content of 18:1 trans fatty acids in subcutaneous fat of persons with coronarographically documented atherosclerosis of the coronary arteries. Ann Nutr Metab 2003;47:302–305.
Brázdová Z, Fiala J, Hrstková H, Bauerová J: Serving size of different food groups as a tool for evaluation of nutritional consumption in gypsy children (in Czech). Hygiena 1998;43:195–206.
- Chen ZY, Pelletier G, Hollywood R, Ratnayake WM: Trans fatty acid isomers in Canadian human milk. Lipids 1995;30:15–21.
- Bysted A, Cold S, Holmer G: An optimized method for fatty acid analysis, including quantification of trans fatty acids, in human adipose tissue by gas-liquid chromatography. Scand J Clin Lab Invest 1999;59:205–214.
- Katan MB, Van Staveren WA, Deurenberg P: Linoleic and trans unsaturated fatty acids content of adipose tissue biopsies as objective indicators of the dietary habits of individuals. Prog Lip Res 1986;25:193–195.
- Van Staveren WA, Deurenberg P, Katan MB, Burema J, deGroot LC, Hoffmans MD: Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long term average fatty acid composition of the diet of separate individuals. Am J Epidemiol 1986;123:455–463.
- Emken EA: Nutrition and biochemistry of trans and positional fatty acids isomers in hydrogenated oils. Annu Rev Nutr 1984;4:339–376.
- Craig Schmidt M, Weete JD, Faircloth SA, Wickwire MA, Livant EJ: The effect of hydrogenated fat in the diet of nursing mothers on lipid composition and prostaglandin content of human milk. Am J Clin Nutr 1984;39:778–786.
- Chappell JE, Chlandinin MT, Kearney-Volpe C: Trans fatty acids in human milk lipids: influence of maternal diet and weight loss. Am J Clin Nutr 1985;42:49–56.
Garza C, Schard R, Hopkinson J: Feeding the premature infant: methods to assess lactation performance; in Hamosh M, Goldman AS (eds): Human Lactation 2. Maternal and Environmental Factors. New York, Plenum Press, 1986, pp 253–262.
- Hachey DL, Thomas MR, Emken EA, Garza C, Brown-Booth L, Adlof RO, Klein PD: Human lactation: maternal transfer of dietary triglycerides labelled with stable isotopes. J Lipid Res 1987;28:1185–1192.
- Boatella J, Rafecas M, Codony R, Gibert A, Rivero M, Tormo R, Infante D, Sanchez-Valverde F: Trans fatty acids content of human milk in Spain. J Pediatr Gastroenterol Nutr 1993;16:432–434.
Brát J: Content of trans fatty acids isomers in edible fats (in Czech). DMEV 2004;7:139–141.
Dostálová J, Brát J, Doležal M, Hanzlík P: Content of trans fatty acids isomers in pastry and ice creams (in Czech). DMEV 2004;7:142–143.
- Mojska H, Socha P, Socha J, Soplinska E, Jaroszewska-Balicka W, Szponar L: Trans fatty acids in human milk in Poland and their association with breastfeeding mothers’ diets. Acta Paediatr 2003;92:1381–1387.
- Kovács A, Funke S, Marosvölgyi T, Burus I, Decsi T: Fatty acids in early human milk after preterm and full-term delivery. J Pediatr Gastroenterol Nutr 2005;41:454–459.
Brázdová Z, Fiala J, Hrstková H: Eating habits of gypsy children (in Czech). Čs Pediatr 1998;53:419–423.
Rambousková J, Dlouhý P, Anděl M: Dietary consumption assessment and evaluation of nutritional status of gypsy pregnant women and their newborn babies; in Abreu L, Sandor J (eds): Monitoring Health Status of Vulnerable Groups in Europe: Past and Present. Pecs, The Compostela Group of Universities and Phoenix/TN, European Thematic Network on Health and Social Welfare Policies, 2006, pp 178–188.
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