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Original Paper

The Germ Cell Nuclear Factor mGCNF Is Expressed in the Developing Nervous System

Süsens U.a · Aguiluz J.B.b · Evans R.M.b · Borgmeyer U.a

Author affiliations

a Zentrum fur Molekulare Neurobiologie, Universität Hamburg, Deutschland; b The Salk Institute for Biological Studies, La Jolla, Calif., USA

Related Articles for ""

Dev Neurosci 1997;19:410–420

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 12, 1997
Issue release date: 1997

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: https://www.karger.com/DNE

Abstract

Using a reinoic acid receptor hybridization probe, we have isolated a mouse embryonic cDNA that encodes the germ cell nuclear factor (mGCNF). The in vitro translated protein binds specifically to the direct repeat of the sequence – AGGTCA – which is characteristic of a subclass of nuclear receptors, albeit with a spacing of zero that is unique among the receptors. Northern analysis shows embryonic expression after mouse gastrulation and during early organogenesis, as well as expression in the adult testis. The message level decreases during embryonic development. Whereas there are two transcripts in the testis, only the larger one is found in embryos. In situ analysis of embryos at days 6.5–10.5 of gestation shows that, in the early postimplantation period, high transcript levels are found in ectodermal cells and in the primitive streak. During further development the expression becomes more restricted. Mainly cells of the developing nervous system are expressing the receptor. Our findings imply that GCNF is involved in two apparently disparate developmental events.

© 1997 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 12, 1997
Issue release date: 1997

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: https://www.karger.com/DNE


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