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Pathological Aspects of Neural Energy Metabolism

Immunohistochemical Study on Superoxide Dismutases in Spinal Cords from Autopsied Patients with Amyotrophic Lateral Sclerosis

Shibata N.a · Asayama K.b · Hirano A.c · Kobayashi M.a

Author affiliations

a Department of Pathology, Tokyo Women's Medical College, Shinjuku, Tokyo, Japan; b Department of Pediatrics, Yamanashi Medical College, Tamaho, Yamanshi, Japan; c Division of Neuropathology, Department of Pathology, Montefiore Medical Center, Bronx, N.Y., USA

Related Articles for ""

Dev Neurosci 1996;18:492–498

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Article / Publication Details

First-Page Preview
Abstract of Pathological Aspects of Neural Energy Metabolism

Received: October 10, 1995
Accepted: January 12, 1996
Published online: August 24, 2009
Issue release date: 1996

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: https://www.karger.com/DNE

Abstract

A role of mutations in the superoxide dismutase (SOD)-1 gene in the pathogenesis of amyotrophic lateral sclerosis (ALS) has been discussed. To investigate immunohistochemical alterations of SOD in the spinal cord affected with this disease, we examined 3 patients in a SODl1 mutation-associated family with ALS, 20 patients with sporadic ALS and 10 control individuals. Lewy body-like hyaline inclusions (LBHIs) were seen in the anterior horn cells of all the familial patients and 10 of the 20 sporadic patients, while skein-like inclusions (SIs) and Bunina bodies (BBs) were present in the 20 sporadic patients but not in the familial patients. The primary antibodies used for immunostaining were rabbit antisera raised against human SOD1 and SOD2. The anti-SOD1 antibody reacted strongly with all LBHIs of each familial patient and with some LBHIs of each sporadic patient. The cytoplasm of morphologically intact and degenerated spinal cord neurons as well as spheroids seen in the cases examined was only weakly stained by the antibody to SOD1 or not at all. The reactive astrocytes displayed weak to moderate staining for SOD1. The anti-SOD2 antibody strongly immunolabeled the reactive astrocytes and microglia. LBHIs of both familial and sporadic ALS were negatively stained for SOD2. Spinal cord neurons and spheroids of each case exhibited no significant SOD2 immunoreactivity. Neither antibodies reacted with SIs nor BBs. These results indicate that SOD1 may be involved in the formative process of LBHIs especially in familial ALS but not always in that of SIs or BBs, and imply that SOD2 may have no connection with any of these ALS-related abnormal structures.

© 1996 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Pathological Aspects of Neural Energy Metabolism

Received: October 10, 1995
Accepted: January 12, 1996
Published online: August 24, 2009
Issue release date: 1996

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: https://www.karger.com/DNE


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