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Translating Neuronal Activity into Dendrite Elaboration: Signaling to the Nucleus

Redmond L.

Author affiliations

Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Ga., USA

Corresponding Author

Dr. Lori Redmond

Department of Pharmacology and Toxicology CB3530

1120 15th Street, Medical College of Georgia

Augusta, GA 30912 (USA)

Tel. +1 706 721 0906, Fax +1 706 721 2347, E-Mail lredmond@mail.mcg.edu

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Neurosignals 2008;16:194–208

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Abstract

Growth and elaboration of neuronal processes is key to establishing neuronal connectivity critical for an optimally functioning nervous system. Neuronal activity clearly influences neuronal connectivity and does so via intracellular calcium signaling. A number of CaMKs and MAPKs convey the calcium signal initiated by neuronal activity. Several of these kinases interact with substrates in close proximity to the plasma membrane and alter dendrite structure locally via these local interactions. However, many calcium-activated kinases, such as Ras-MAPK and CaMKIV, target proteins in the nucleus, either by activating a downstream substrate that is a component of a signaling cascade or by directly acting within the nucleus. It is the activation of nuclear signaling and gene transcription that is thought to mediate global changes in dendrite complexity. The identification of calcium-sensitive transcription factors and transcriptional coactivators provides substantial evidence that gene transcription is a prevalent mechanism by which neuronal activity is translated into changes in dendrite complexity. The present review presents an overview of the role of neuronal activity in the development of neuronal dendrites, the signaling mechanisms that translate neuronal activity into gene transcription, and the transcribed effectors that regulate dendrite complexity.

© 2008 S. Karger AG, Basel


References

  1. Gilbert CD: Microcircuitry of the visual cortex. Annu Rev Neurosci 1983;6:217–247.
  2. Hausser M, Spruston N, Stuart GJ: Diversity and dynamics of dendritic signaling. Science 2000;290:739–744.
  3. Segev I, London M: Untangling dendrites with quantitative models. Science 2000;290:744–750.
  4. O’Leary DDM, Koester SE: Development of projection neuron types, axon pathways, and patterned connections of the mammalian cortex. Neuron 1993;10:991–1006.
  5. Scott EK, Luo L: How do dendrites take their shape? Nat Neurosci 2001;4:359–365.
  6. Bradke F, Dotti CG: Establishment of neuronal polarity: lessons from cultured hippocampal neurons. Curr Opin Neurobiol 2000;10:574–581.
  7. Polleux F, Morrow T, Ghosh A: Semaphorin 3A is a chemoattractant for cortical apical dendrites. Nature 2000;404:567–573.
  8. Miller M: Maturation of rat visual cortex. I. A quantitative study of Golgi-impregnated pyramidal neurons. J Neurocyt 1981;10:859–878.
  9. Miller MW: Maturation of rat visual cortex. III. Postnatal morphogenesis and synaptogenesis of local circuit neurons. Brain Res Dev Brain Res 1986;25:271–285.
  10. Miller M, Peters A: Maturation of rat visual cortex. II. A combined Golgi-electron microscope study of pyramidal neurons. J Comp Neurol 1981;203:555–573.
  11. Wise SP, Fleshman JW Jr, Jones EG: Maturation of pyramidal cell form in relation to developing afferent and efferent connections of rat somatic sensory cortex. Neuroscience 1979;4:1275–1297.
  12. Purpura DP: Dendritic differentiation in human cerebral cortex: normal and aberrant developmental patterns. Adv Neurol 1975;12:91–116.
  13. Fiala JC, Feinberg M, Popov V, Harris KM: Synaptogenesis via dendritic filopodia in developing hippocampal area CA1. J Neurosci 1998;18:8900–8911.
  14. Dailey ME, Smith SJ: The dynamics of dendritic structure in developing hippocampal slices. J Neurosci 1996;16:2983–2994.
  15. Greenough WT, Chang FL: Dendritic pattern formation involves both oriented regression and oriented growth in barrels of mouse somatosensory cortex. Brain Res 1988;471:148–152.
  16. Malun D, Brunjes PC: Development of olfactory glomeruli: temporal and spatial interactions between olfactory receptor axons and mitral cells in opossums and rats. J Comp Neurol 1996;368:1–16.
  17. Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, Vermeer H, Toonen RF, Hammer RE, van der Berg TK, Missler M, Geuze HJ, Sudhol TC: Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science 2000;287:864–869.
  18. Crowley JC, Katz LC: Early development of ocular dominance columns. Science 2000;290:1321–1324.
  19. Wu GY, Malinow R, Cline HT: Maturation of a central glutamergic synapse. Science 1996;274:972–976.
  20. Wu GY, Zou DJ, Rajan I, Cline HT: Dendritic dynamics in vivo change during neuronal maturation. J Neurosci 1999;19:4427–4483.
  21. Rajan I, Cline HT: Glutamate receptor activity is required for normal development of tectal cell dendrites in vivo. J Neurosci 1998;18:7836–7846.
  22. Coleman PD, Riesen AH: Environmental effects on cortical dendritic fields. I. Rearing in the dark. J Anat 1968;102:363–374.
  23. Wiesel TN, Hubel DH: Effects of visual deprivation on morphology and physiology of cells in the cat’s lateral geniculate body. J Neurophysiol 1963;26:978–993.
  24. Harris RM, Woolsey TA: Morphology of Golgi-impregnated neurons in mouse cortical barrels following vibrissae damage at different postnatal ages. Brain Res 1979;161:143–149.
  25. Steffen H, Van der Loos H: Early lesions of mouse vibrissal follicles: their influence on dendritic orientation in the cortical barrelfield. Exp Brain Res 1980;40:410–431.
    External Resources
  26. Inglis FM, Zuckerman KE, Kalb RG: Experience-dependent development of spinal motor neurons. Neuron 2000;26:299–305.
  27. Rakic P: Role of cell interaction in development of dendritic patterns. Adv Neurol 1975;12:117–134.
  28. Altman J, Anderson WJ: Experimental reorganization of the cerebellar cortex. I. Morphological effects of elimination of all microneurons with prolonged X-irradiation started at birth. J Comp Neurol 1972;146:355–406.
  29. Redmond L, Kashani AH, Ghosh A: Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. Neuron 2002;34:999–1010.
  30. Engert F, Bonhoeffer T: Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 1999;399:66–70.
  31. Maletic-Savatic M, Malinow R, Svoboda K: Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. Science 1999;283:1923–1927.
  32. Holloway RL: Dendritic branching: some preliminary results of training and complexity in rat visual cortex. Brain Res 1966;2:393–396.
  33. Greenough WT, Volkmar FR: Pattern of dendritic branching in occipital cortex of rats reared in complex environments. Exp Neurol 1973;40:491–504.
  34. Volkmar FR, Greenough WT: Rearing complexity affects branching of dendrites in the visual cortex of the rat. Science 1972;176:1145–1147.
  35. Sin WC, Haas K, Ruthazer ES, Cline HT: Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases. Nature 2002;419:475–480.
  36. Vaillant AR, Zanassi P, Walsh GS, Aumont A, Alonso A, Miller FD: Signaling mechanisms underlying reversible, activity-dependent dendrite formation. Neuron 2002;34:985–998.
  37. Yu X, Malenka RC: Beta-catenin is critical for dendritic morphogenesis. Nat Neurosci 2003;6:1169–1177.
  38. Gaudilliere B, Konishi Y, de la Iglesia N, Yao G, Bonni A: A CaMKII-NeuroD signaling pathway specifies dendritic morphogenesis. Neuron 2004;41:229–241.
  39. Wayman GA, Impey S, Marks D, Saneyoshi T, Grant WF, Derkach V, Soderling TR: Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2. Neuron 2006;50:897–909.
  40. Rakic P, Sidman RL: Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice. J Comp Neurol 1973;152:133–161.
  41. Sotelo C: Anatomical, physiological and biochemical studies of the cerebellum from mutant mice. II. Morphological study of cerebellar cortical neurons and circuits in the weaver mouse. Brain Res 1975;94:19–44.
  42. Mason CA, Morrison ME, Ward MS, Zhang Q, Baird DH: Axon-target interactions in the developing cerebellum. Perspect Dev Neurobiol 1997;5:69–82.
  43. Benes FM, Parks TN, Rubel EW: Rapid dendritic atrophy following deafferentation: an EM morphometric analysis. Brain Res 1977;122:1–13.
  44. Deitch JS, Rubel EW: Afferent influences in brain stem auditory nuclei of the chicken: time course and specificity of dendritic atrophy following deafferentation. J Comp Neurol 1984;229:66–79.
  45. Purves D, Hume RI: The relation of postsynaptic geometry to the number of presynaptic axons that innervate autonomic ganglion cells. J Neurosci 1981;1:441–452.
  46. Kalb RG: Regulation of motor neuron dendrite growth by NMDA receptor activation. Development 1994;120:3063–3071.
  47. Ivanco TL, Racine RJ, Kolb B: Morphology of layer III pyramidal neurons is altered following induction of LTP in sensorimotor cortex of the freely moving rat. Synapse 2000;37:16–22.
  48. Bartsch D, Ghirardi M, Skehel PA, Karl KA, Herder SP, Chen M, Bailey CH, Kandel ER: Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell 1995;83:979–992.
  49. Kozorovitskiy Y, Gross CG, Kopil C, Battaglia, L, McBreen M, Stranahan AM, Gould E: Experience induces structural and biochemical changes in the adult primate brain. Proc Natl Acad Sci USA 2005;102:17478–17482.
  50. Hille B: Ion Channels of Excitable Membranes, ed 3. Sunderland, Sinauer Associates, 2001.
  51. Lohmann C, Wong ROL: Regulation of dendritic growth and plasticity by local and global calcium dynamics. Cell Calcium 2005;47:403–409.
    External Resources
  52. Lohmann C, Finski A, Bonhoeffer T: Local calcium transients regulate the spontaneous motility of dendritic filopodia. Nat Neurosci 2005;8:305–312.
  53. Ghosh A, Greenberg ME: Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 1995;268:239–247.
  54. Hardingham GE, Chawla S, Cruzalegui FH, Bading H: Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels. Neuron 1999;22:789–798.
  55. West AE, Griffith EC, Greenberg ME: Regulation of transcription factors by neuronal activity. Nat Rev Neurosci 2002;3:921–931.
  56. Sheng M, Hoogenraad CC: The postsynaptic architecture of excitatory synapses: a more quantitative view. Annu Rev Biochem 2007;76:823–847.
  57. Jakowec MW, Fox AJ, Martin LJ, Kalb RG: Quantitative and qualitative changes in AMPA receptor expression during spinal cord development. Neuroscience 1995;67:893–907.
  58. Inglis FM, Crockett R, Korada S, Abraham, WC, Hollmann M, Kalb RG: The AMPA receptor subunit GluR1 regulates dendritic architecture of motor neurons. J Neurosci 2002;22:8042–8052.
  59. Iwasato T, Datwani A, Wolf AM, Nishiyama H, Taguchi Y, Tonegawa S, Knöpfel T, Erzurumlu RS, Itohara S: Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature 2000;406:726–731.
  60. Datwani A, Iwasato T, Itohara S, Erzurumlu RS: NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the Barrel cortex. Mol Cell Neurosci 2002;21:477–492.
  61. Tyndall SJ, Patel SJ, Walikonis RS: Hepatocyte growth factor-induced enhancement of dendritic branching is blocked by inhibitors of N-methyl-D-aspartate receptors and calcium/calmodulin-dependent kinases. J Neurosci Res 2007;85:2343–2351.
  62. Borodinsky LN, O’Leary DO, Neale JH, Vicini S, Coso OA, Fiszman ML: GABA-induced neurite outgrowth of cerebellar granule cells is mediated by GABAA receptor activation, calcium influx and CaMKII and erk1/2 pathways. J Neurochem 2003;84:1411–1420.
  63. Kobayashi T, Yamada Y, Fukao M, Tsutsuura M, Tohse N: Regulation of Cav1.2 current: Interaction with intracellular molecules. J Pharmacol Sci 2007;103:347–353.
  64. Burgoyne RD: Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signaling. Nat Rev Neurosci 2007;8:182–193.
  65. Hardingham GE, Arnold FJ, Bading H: Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nat Neurosci 2001;4:261–267.
  66. Hardingham GE, Chawla S, Johnson CM, Bading H: Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature 1997;385:260–265.
  67. Ehlers MD, Zhang S, Bernhadt JP, Huganir RL: Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit. Cell 1996;84:745–755.
  68. Dolmetsch RE, Pajvani U, Fife K, Spotts JM, Greenberg ME: Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science 2001;294:333–339.
  69. Fink CC, Bayer KU, Myers JW, Ferrell JE Jr, Schulman H, Meyer T: Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron 2003;39:283–297.
  70. Bading H, Ginty DD, Greenberg ME: Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 1993;260:181–186.
  71. Hook SS, Means AR: Ca2+/CaM-dependent kinases: from activation to function. Annu Rev Pharmacol Toxicol 2001;41:471–505.
  72. Soderling TR: The Ca2+-calmodulin-dependent protein kinase cascade TIBS 1999;24:232–236.
  73. Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Segi E, Arakawa Y, Furuyashiki T, Narumiya S, Bito H: Molecular cloning and characterization of CLICK-III/CaMKIγ, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). J Biol Chem 2003;278:18597–18605.
  74. Rosen LB, Ginty DD, Weber MJ, Greenberg ME: Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron 1994;12:1207–1221.
  75. Cullen PJ, Lockyer PJ: Integration of calcium and ras signaling. Nat Rev Mol Cell Biol 2002;3:339–348.
  76. Ferguson GD, Storm DR: Why calcium-stimulated adenylyl cyclases? Physiology (Bethesda) 2004;19:271–276.
  77. Abdel-Majid RM, Leong WL, Schalkwyk LC, Smallman DS, Wong ST, Storm DR, Fine A, Dobson MJ, Guernsey DL, Neumann PE: Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex. Nat Genet 1998;19:289–291.
  78. Welker E, Armstrong-James M, Bronchti G, Ourednik W, Gheorghita-Baechler F, Dubois R, Guernsey DL, Van der Loos H, Neumann PE: Altered sensory processing in the somatosensory cortex of the mouse mutant barrelless. Science 1996;271:1864–1867.
  79. Westenbroek RE, Ahlijanian MK, Catterall WA: Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons. Nature 1990;347:281–284.
  80. Hardingham GE, Arnold FJL, Bading H: A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Nat Neurosci 2001;4:565–566.
  81. Lisman J, Schulman H, Cline H: The molecular basis of CaMKII function in synaptic and behavioural memory. Nat Rev Neurosci 2002;3:175–190.
  82. Wu GY, Cline HT: Stabilization of dendritic arbor structure in vivo by CaMKII. Science 1998;279:222–226.
  83. Zou DJ, Cline HT: Postsynaptic calcium/calmodulin-dependent protein kinase II is required to limit elaboration of presynaptic and postsynaptic neuronal arbors. J Neurosci 1999;19:8909–8918.
  84. Jensen KF, Ohmstede CA, Fisher RS, Sahyoun N: Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex. Proc Natl Acad Sci USA 1991;88:2850–2853.
  85. Wayman GA, Kaech S, Grant WF, Davare M, Impey S, Tokumitsu H, Nazaki N, Banker G, Soderling TR: Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I. J Neurosci 2004;24:3786–3794.
  86. Kamata A, Sakagami H, Tokumitsu H, Sanda M, Owada Y, Fukunaga K, Kondo H: Distinct developmental expression of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases and their involvement in hippocampal dendritic formation. Neurosci Lett 2007;423:143–148.
  87. Schmitt JM, Wayman GA, Nozaki N, Soderling TR: Calcium activation of ERK mediated by calmodulin kinase I. J Biol Chem 2004;279:24064–24072.
  88. Picciotto MR, Zoli M, Bertuzzi G, Nairn AC: Immunochemical localization of calcium/calmodulin-dependent protein kinase I. Synapse 1995;20:75–84.
  89. Stedman DR, Uboha NV, Stedman TT, Nairn AC, Picciotto MR: Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-alpha depends on a nuclear export signal in its regulatory domain. FEBS Lett 2004;566:275–280.
  90. Uboha NV, Flajolet M, Nairn AC, Picciotto MR: A calcium- and calmodulin-dependent kinase Iα/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth. J Neurosci 2007;27:4413–4423.
  91. Takemoto-Kimura S, Ageta-Ishihara N, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, Fujii H, Fuse T, Hoshino M, Suzuki S, Kojima M, Mishina M, Okuno H, Bito H: Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIγ. Neuron 2007;54:755–770.
  92. Kumar V, Zhang M-X, Swank, MW, Kunz J, Wu G-Y: Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways. J Neurosci 2005;25:11288–11299.
  93. Chen Y, Wang PY, Ghosh A: Regulation of cortical dendrite development by Rap1 signaling. Mol Cell Neurosci 2005;28:215–228.
  94. Impey S, Obrietan K, Wong ST, Poser S, Yano S, Wayman G, Deloulme JC, Chan G, Storm DR: Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron 1998;21:869–883.
  95. Parrish JZ, Emoto K, Kim MD, Jan YN: Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. Annu Rev Neurosci 2007;30:399–423.
  96. Ghosh A, Carnahan J, Greenberg ME: Requirement for BDNF in activity-dependent survival of cortical neurons. Science 1994;263:1618–1623.
  97. Johannessen M, Delghandi MP, Moens U: What turns CREB on? Cell Signalling 2004;16:1211–1227.
  98. Wu GY, Diesseroth K, Tsien RW: Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 2001;98:2802–2813.
  99. Enslen H, Sun P, Brickey D, Soderling SH, Klamo E, Soderling TR: Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. J Biol Chem 1994;269:15520–15527.
  100. Ince-Dunn G, Hall BJ, Hu SC, Ripley B, Huganir RL, Olson JM, Tapscott SJ, Ghosh A: Regulation of thalamocortical patterning and synaptic maturation by NeuroD2. Neuron 2006;49:683–695.
  101. Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A: Dendrite development regulated by CREST, a calcium-regulated transcriptional activator. Science 2004;303:197–202.
  102. Mao Z, Bonni A, Xia F, Nadal-Vicens M, Greenberg ME: Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science 1999;286:785–790.
  103. Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME: Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 2006;311:1008–1012.
  104. Shalizi A, Gaudilliere B, Yuan Z, Stegmuller J, Shirogane T, Ge Q, Tan Y, Schulman B, Harper JW, Bonni A: A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science 2006;311:1012–1007.
  105. Shalizi A, Bilimoria PM, Stegmuller J, Gaudilliere B, Yang Y, Shuai K, Bonni A: PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. J Neurosci 2007;27:10037–10046.
  106. Ramos B, Gaudilliere B, Bonni A, Gill G: Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation. Proc Natl Acad Sci USA 2007;104:9882–9887.
  107. Kashani AH, Qiu Z, Jurata L, Lee SK, Pfaff S, Goebbels S, Nave KA, Ghosh A: Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J Neurosci 2006;26:8398–8408.
  108. Gomez-Ospina N, Tsuruta F, Barreto-Chang O, Hu L, Dolmetsch R: The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor. Cell 2006;127:591–606.
  109. Nedivi E: Molecular analysis of developmental plasticity in neocortex. J Neurobiol 1999;41:135–147.
  110. Sheng M, Kim MJ: Postsynaptic signaling and plasticity mechanisms. Science 2002;298:776–780.
  111. Conkright MD, Guzman E, Flechner L, Su AI, Hogenesch JB, Montminy M: Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. Mol Cell 2003;11:1101–1108.
  112. Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, Best J, Chen H, Jenner R, Herbolsheimer E, Jacobsen E, Kadam S, Ecker JR, Emerson B, Hogenesch JB, Unterman T, Young RA, Montminy M: Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci USA 2005;102:4459–4464.
  113. Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM, McWeeney S, Dunn JJ, Mandel G, Goodman RH: Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 2004;119:1041–1054.
  114. Shieh PB, Hu S-C, Bobb K, Timmusk T, Ghosh A: Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron 1998;20:727–740.
  115. Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME: Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 1998;20:709–726.
  116. Tabuchi A, Nakaoka R, Amano K, Yukimine M, Andoh T, Kuraishi Y, Tsuda M: Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels. J Biol Chem 2000;275:17269–17275.
  117. Tabuchi A, Sakaya H, Kisukeda T, Fushiki H, Tsuda M: Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I. J Biol Chem 2002;277:35920–35931.
  118. Dijkhuizen PA, Ghosh A: BDNF regulates primary dendrite formation in cortical neurons via the PI3-kinase and MAP kinase signaling pathways. J Neurobiol 2005;62:278–288.
  119. McAllister AK, Lo DC, Katz LC: Neurotrophins regulate dendritic growth in developing visual cortex. Neuron 1995;15:791–803.
  120. Horch HW, Kruttgen A, Portbury SD, Katz LC: Destabilization of cortical dendrites and spines by BDNF. Neuron 1999;23:353–354.
  121. Wirth MJ, Brun A, Grabert J, Patz S, Wahle P: Accelerated dendritic development of rat cortical pyramidal cells and interneurons after biolistic transfection with BDNF and NT4/5. Development 2003;130:5827–5838.
  122. Horch HW, Katz LC: BDNF release from single cells elicits local dendritic growth in nearby neurons. Nat Neurosci 2002;5:1177–1184.
  123. Jin X, Hu H, Mathers PH, Agmon A: Brain-derived neurotrophic factor mediates activity-dependent dendritic growth in nonpyramidal neocortical interneurons in developing organotypic cultures. J Neurosci 2003;23:5662–5673.
  124. McAllister AK, Katz LC, Lo DC: Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendrite growth. Neuron 1997;18:767–778.
  125. Gorski JA, Zeiler SR, Tamowski S, Jones KR: Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 2003;23:6856–6865.
  126. Xu B, Zang K, Ruff NL, Zhang YA, McConnell SK, Stryker MP, Reichardt LF: Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron 2000;26:233–245.
  127. Du J, Feng L, Yang F, Lu B: Activity- and Ca2+-dependent modulation of surface expression of brain-derived neurotrophin factor receptors in hippocampal neurons. J Cell Biol 2000;150:1423–1433.
  128. Nagappan G, Lu B: Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Trends in Neurosci 2005;28:464–471.
  129. Kingsbury TJ, Murray PD, Bambrick LL, Krueger BK: Ca(2+)-dependent regulation of TrkB expression in neurons. J Biol Chem 2003;278:40744–40748.
  130. Yacoubian TA, Lo DC: Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth. Nat Neurosci 2000;3:342–349.
  131. Nedivi E, Wu GY, Cline HT: Promotion of dendritic growth by CPG15, an activity-induced signaling molecule. Science 1998;281:1863–1866.
  132. Fujino T, Lee WC, Nedivi E: Regulation of cpg15 by signaling pathways that mediate synaptic plasticity. Mol Cell Neurosci 2003;24:538–554.
  133. Harwell C, Burbach B, Svoboda K, Nedivi E: Regulation of cpg15 expression during single whisker experience in the barrel cortex of adult mice. J Neurobiol 2005;65:85–96.
  134. Naeve GS, Ramakrishnan M, Kramer R, Hevroni D, Citri Y, Theill LE: Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. Proc Natl Acad Sci USA 1997;94:2648–2653.
  135. Yu X, Malenka RC: Multiple functions for the cadherin/catenin complex during neuronal development. Neuropharmacology 2004;47:779–786.
  136. Vo N, Klein ME, Varlamova O, Keller DM, Yamamoto T, Goodman RH, Impey S: A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci USA 2005;102:16426–16431.
  137. Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, Greenberg ME: A brain-specific microRNA regulates dendritic spine development. Nature 2006;439:283–289.
  138. Van Aelst L, Cline HT: Rho GTPases and activity-dependent dendrite development. Curr Opin Neurobiol 2004;14:297–304.

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Published online: February 05, 2008
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eISSN: 1424-8638 (Online)

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