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Original Paper

Free Access

Possible Association of Amelogenin to High Caries Experience in a Guatemalan-Mayan Population

Deeley K.a · Letra A.a · Rose E.K.a · Brandon C.A.a · Resick J.M.a · Marazita M.L.a, c-e · Vieira A.R.a-d

Author affiliations

Departments of aOral Biology and bPediatric Dentistry, and cCenter for Craniofacial and Dental Genetics, School of Dental Medicine, dDepartment of Human Genetics, Graduate School of Public Health, and eDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pa., USA

Corresponding Author

Alexandre R. Vieira

614 Salk Hall, Department of Oral Biology

School of Dental Medicine, University of Pittsburgh

3501 Terrace Street, Pittsburgh, PA 15261 (USA)

Tel. +1 412 383 8972, Fax +1 412 624 3080, E-Mail arv11@dental.pitt.edu

Related Articles for ""

Caries Res 2008;42:8–13

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There is evidence for a genetic component in caries susceptibility, but the disease is greatly influenced by environmental factors, which are extremely difficult to control in humans. For the present study, we used DNA samples collected from 110 unrelated, non-cleft individuals older than 12 years of age from Tiquisate, Guatemala: a population with similar cultural, dietary and hygiene habits, similar access to the dentist and fluoride exposure. Forty-four individuals were designated ‘very low caries experience’ (DMFT ≤2), and 66 were designated ‘higher caries experience’ (DMFT ≧3). Single-nucleotide polymorphism markers were genotyped in selected candidate genes (ameloblastin, amelogenin, enamelin, tuftelin-1, and tuftelin interacting protein 11) that influence enamel formation. Having at least one copy of the rare amelogenin marker allele was associated with increased age-adjusted caries experience. This association was stronger in individuals with higher DMFT (DMFT ≧20; p = 0.0000001). Our results suggest that variation in amelogenin may contribute to caries susceptibility in the population studied. The approach of comparing individuals with extremely distinct caries experiences could be valuable for decreasing the potential influence of environmental factors on genetic studies of caries.

© 2007 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 19, 2007
Accepted: August 20, 2007
Published online: November 27, 2007
Issue release date: January 2008

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE

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