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Review Article

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Neuropsychiatric Manifestations in Mild Cognitive Impairment: A Systematic Review of the Literature

Apostolova L.G.a, b · Cummings J.L.a, c

Author affiliations

aDepartment of Neurology, bLaboratory of Neuro Imaging, and cDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, Calif., USA

Corresponding Author

Liana G. Apostolova, MD

Alzheimer’s Disease Research Center

10911 Weyburn, 2nd floor

Los Angeles, CA 90095 (USA)

Tel. +1 310 794 2551, Fax +1 310 794 3148, E-Mail lapostolova@mednet.ucla.edu

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Dement Geriatr Cogn Disord 2008;25:115–126

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Background: Mild cognitive impairment (MCI) is an etiologically heterogeneous condition that is characterized by cognitive changes without impairment of activities of daily living and insufficient to represent dementia. MCI is an important risk state for dementia. Neuropsychiatric symptoms may be present in MCI. Methods: We executed a PubMed search for articles on the neuropsychiatric manifestations in MCI and reviewed their findings. Results: Behavioral abnormalities are reported in 35–75% of MCI patients with the most common being depression, apathy, anxiety and irritability. The observed variability in symptom prevalence can be explained by the different sampling methods, MCI diagnostic criteria and behavioral instruments used. There is a compelling body of evidence that MCI patients with behavioral features are more prone to develop Alzheimer’s disease (AD) than patients without these features. Conclusions: Neuropsychiatric symptoms are common features of MCI. The behavioral changes observed in MCI are similar to those of AD and may help identify the subgroup of MCI patients with prodromal AD. Large prospective longitudinal studies would greatly contribute to our understanding of the epidemiology, diagnostic and prognostic value of the neuropsychiatric features in MCI.

© 2007 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Review Article

Accepted: November 02, 2007
Published online: December 14, 2007
Issue release date: February 2008

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

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