Brain, Behavior and Evolution
Original Paper
Catecholamines and Indoleamines in the Central Nervous System of a Urodele Amphibian: A Microdissection Study with Emphasis on the Distribution of Epinephrine (Part 1 of 2)Lowry C.A.a · Renner K.J.b · Moore F.L.aa Department of Zoology, Oregon State University, Corvallis, Oreg., b Biomedical Sciences Department, Southwest Missouri State University Springfield, Mo., USA
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Article / Publication Details
Published online: January 08, 2008
Issue release date: 1996
Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0
ISSN: 0006-8977 (Print)
eISSN: 1421-9743 (Online)
For additional information: https://www.karger.com/BBE
Abstract
Individual brain nuclei and regions of the central nervous system of adult male roughskin newts (Taricha granulosa) were microdissected and the concentrations of norepinephrine, epinephrine, 3,4-dihydroxyphenylacetic acid, dopamine, 5-hydroxyindoleacetic acid, and serotonin were determined using high performance liquid chromatography (HPLC) with electrochemical detection. The pattern of distribution of these catecholamines and indoleamines revealed many similarities between this urodele and other vertebrates. The highest concentrations of biogenic amines were observed in brainstem, hypothalamic, and basal forebrain structures; the lowest concentrations were observed in the internal granule layer of the olfactory bulb and pallial structures of the telencephalon. High concentrations of catecholamines and indoleamines were found in hypothalamic periventricular regions that are known to include cerebrospinal fluid-contacting, monoamine-containing neuronal cell bodies. The rostral diencephalon, which included the preoptic recess organ, had high concentrations of the primary catecholamines, norepinephrine and dopamine, and extremely high concentrations of the secondary catecholamine epinephrine. The dorsomedial infundibular hypothalamic region, which included the paraventricular organ, had high concentrations of dopamine and serotonin. The lateral infundibular hypothalamic region, which included the nucleus infundibularis dorsalis, had high concentrations of each of the biogenic amines. The results revealed unique patterns of distribution for each of the catecholamines and indoleamines studied, and provided evidence that regions of the hypothalamus that include cerebrospinal fluid-contacting, monoamine-containing neuronal cell bodies are focal regions for the metabolism of multiple biogenic amines.
© 1996 S. Karger AG, Basel
Article / Publication Details
Published online: January 08, 2008
Issue release date: 1996
Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0
ISSN: 0006-8977 (Print)
eISSN: 1421-9743 (Online)
For additional information: https://www.karger.com/BBE
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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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