European Neurology
Increase in Kaolin-Induced Intracranial Hypertension after Decentralization of the Superior Cervical Sympathetic Ganglia in RabbitsEdvinsson L. · Nielsen K.C. · Owman C. · West K.A.Departments of Histology and Neurosurgery A, University of Lund, Lund, and Neurosurgical Clinic, University Hospital, Umeå
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Article / Publication Details
Received: October 16, 1973
Accepted: January 09, 1974
Published online: January 23, 2008
Issue release date: 1974
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
Abstract
Intracranial hypertension, used here as an experimental model to exaggerate changes in ventricular fluid pressure (VFP), was produced in rabbits by cisternal injection of kaolin, which impairs the outflow of cerebrospinal fluid. Two days after the kaolin injection, a cannula was implanted into the left lateral ventricle for subsequent continuous measurement of VFP during 25–30 h in nonanesthetized animals. Decentralization (denervation of the superior cervical sympathetic ganglia) was performed by excision of a small portion of the sympathetic trunk immediately below the ganglia. 4–6 h after decentralization, the VFP was almost 150 mm saline, i.e. 40 mm more than the kaolin-treated but nondenervated controls. Two weeks after decentralization the VFP was increased up to 200 mm, which was 100 mm more than in the control animals. In fact, most of the animals in this group died in the course of the experiment, due to the excessive intracranial hypertension which was more than a tenfold increase compared to normal rabbits. It is suggested that the increased VFP following sympathetic denervation is a result of increased cerebral blood volume (vasodilation) together with increased production of cerebrospinal fluid (loss of inhibitory adrenergic nerve activity in the choroid plexuses).
© 1974 S. Karger AG, Basel
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Article / Publication Details
Received: October 16, 1973
Accepted: January 09, 1974
Published online: January 23, 2008
Issue release date: 1974
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
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