European Neurology
Original Paper
Immunoglobulin Characterization by Bacterial Absorption of Antibrain Antibodies in Multiple SclerosisRyberg B. · Kronvall G.Department of Neurology and Department of Medical Microbiology, University of Lund, Sweden
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Article / Publication Details
Received: July 04, 1980
Accepted: October 09, 1980
Published online: January 29, 2008
Issue release date: 1981
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
Abstract
Complement-fixing (CF) antibrain antibodies are frequently found in serum and CSF in multiple sclerosis (MS). They represent several specificities and appear to be synthesized on both sides of the blood-brain barrier. Five sera and six CSF samples from 11 MS patients, representing 6 different specificities of antibrain antibodies, were absorbed with a series of bacterial strains with affinity for various immunoglobulins. Reactivity with brain preparations was eliminated by absorption with the following IgG absorbents: Staphylococcus aureus strain Cowan I, group A streptococcus strain A R1, and group G streptococcus strain G 148, but not by absorption with strains with low or no affinity for IgG. The results indicate in all tested samples the IgG1 and/or IgG2 nature of the antibrain antibodies.
© 1981 S. Karger AG, Basel
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Article / Publication Details
Received: July 04, 1980
Accepted: October 09, 1980
Published online: January 29, 2008
Issue release date: 1981
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
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