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Behavioural Aspects, Food and Nutrition in Later Life

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Food and Drug Interaction: Consequences for the Nutrition/Health Status

Genser D.

Author affiliations

Gesundheit Österreich GmbH (GÖG)/Österreichisches Bundesinstitut für Gesundheitswesen (ÖBIG) – Vergiftungsinformationszentrale, Wien, Austria

Corresponding Author

DDr. Dieter Genser

Gesundheit Österreich GmbH (GÖG)/Österreichisches Bundesinstitut für Gesundheitswesen (ÖBIG) – Vergiftungsinformationszentrale, Leitstelle 6Q

Währinger Gürtel 18–20, AT–1090 Wien (Austria), Tel. +43 1 40400/2222

Fax +43 1 40400/4225, E-Mail Dieter.Genser@meduniwien.ac.at

Related Articles for ""

Ann Nutr Metab 2008;52:29–32

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Food-drug interactions are defined as alterations of pharmacokinetics or pharmacodynamics of a drug or nutritional element or a compromise in nutritional status as a result of the addition of a drug. Elderly patients are particularly at risk because more than 30% of all the prescription drugs are taken by this population. Failure to identify and properly manage drug-nutrient interactions can lead to serious consequences. For instance, drug-nutrient interactions can result in reduced absorption of certain oral antibiotics and may lead to suboptimal antibiotic concentrations at the site of infection. This predisposes the patient to treatment failure. Induction or inhibition of enzymes in the gut by nutrients may lead to a significant change in oral bioavailability of drugs or vice versa. For example, grapefruit juice is a selective intestinal CYP3A4 inhibitor. The overall exposure of some drugs can be increased by more than fivefold when taken with grapefruit juice and increase the risk of adverse effects. The use of certain drugs may affect GI tract function and may lead to a loss of bodily electrolytes and fluid. Limiting drug prescriptions to essential medications for as short a period as possible and periodic re-evaluations of the treatment chosen are essential to minimize adverse drug-nutrient interactions.

© 2008 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Behavioural Aspects, Food and Nutrition in Later Life

Published online: March 07, 2008
Issue release date: March 2008

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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