European Neurology
Original Paper
Cerebrospinal Fluid Neuropeptide Y in Alzheimer’s DiseaseAlom J.A.a · Galard R.b · Catalan R.b · Castellanos J.M.b · Schwartz S.b · Tolosa E.aaDepartment of Neurology, Hospital Clinic i Provincial, Faculty of Medicine, University of Barcelona; bDepartment of Biochemistry, Hospital General Vall d’Hebron, Barcelona, Spain
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Article / Publication Details
Received: June 22, 1989
Accepted: October 09, 1989
Published online: February 14, 2008
Issue release date: 1990
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
Abstract
The cerebrospinal fluid neuropeptide Y level was measured by radioimmunoassay in 20 patients with probable Alzheimer’s disease and in 19 controls. The mean level was lower in patients (69.5 ± 36.7 pg/ml) than in controls (103 ± 21.8 pg/ml; p < 0.001). Patients with a disease duration of >2 years had cerebrospinal fluid neuropeptide Y levels lower than those with shorter disease duration (p < 0.02). These results suggest that neuropeptide Y containing cells may be involved in Alzheimer’s disease. No correlation was found between neuropeptide Y levels and degree of cognitive impairment or age at disease onset.
© 1990 S. Karger AG, Basel
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Article / Publication Details
Received: June 22, 1989
Accepted: October 09, 1989
Published online: February 14, 2008
Issue release date: 1990
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
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