Neuropsychobiology

 

Relationship between Response to Phenelzine and MAO Inhibition in a Clinical Trial of Phenelzine, Amitriptyline and Placebo

Raft D. · Davidson J. · Wasik J. · Mattox A.

Author affiliations

Dental Research Center, University of North Carolina Pain Clinic, Chapel Hill, N.C.

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Neuropsychobiology 1981;7:122–126

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: February 19, 2008
Issue release date: 1981

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

This report examines the hypothesis that for phenelzine to be more effective than placebo it is necessary to achieve at least 80% inhibition of platelet MAO activity. This hypothesis was examined in the context of a double-blind comparison of phenelzine, amitriptyline and placebo in depressed patients. When phenelzine became significantly more effective than placebo at 4 weeks, the average MAO inhibition was 85%. By the 5th week, with MAO inhibition greater than 90%, phenelzine was significantly more effective than amitriptyline. A highly significant correlation was noted between improvement and MAO inhibition within the phenelzine group.

© 1981 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: February 19, 2008
Issue release date: 1981

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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