European Surgical Research

Original Paper

Effect of the Portacaval Shunt on Reperfusion Injury after 65% Hepatectomy in Pigs

Farantos C.a · Arkadopoulos N.a · Theodoraki K.a · Kostopanagiotou G.d · Katis K.e · Tzavara K.f · Andreadou I.g · Dimopoulou K.b · Hatzoudi E.c · Sidiropoulou T.d · Skalkidis I.a · Paphiti A.b · Smyrniotis V.a

Author affiliations

aSecond Department of Surgery, and Departments of bPathology and cMicrobiology, Athens University School of Medicine, Aretaieion University Hospital, dSecond Department of Anesthesiology, Athens University School of Medicine, Attikon University Hospital, eDepartment of Surgery, 401 Military Hospital, fFirst Department of Internal Medicine, Red Cross Hospital, and gDepartment of Pharmaceutical Chemistry, Athens University School of Pharmacy, Athens, Greece

Keywords: ApoptosisHepatectomyIschemia/reperfusionLiver regenerationPigsPortal blood flow

Related Articles for ""
Eur Surg Res 2008;40:347–353
https://doi.org/10.1159/000118031

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 22, 2007
Accepted: October 02, 2007
Published online: February 26, 2008
Issue release date: May 2008

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 3

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

Abstract

Background: Portal flow diversion by portacaval shunts (PCS) has been shown to prevent primary graft nonfunction in liver transplantation using small-for-size grafts. In this study, we examine whether PCS can improve reperfusion injury after major hepatectomy in pigs. Materials and Methods: In 14 pigs, a partial PCS was constructed following 65% hepatectomy and 1 h of inflow ischemia. During 24 h of reperfusion, the shunt was either closed (group A, n = 7) or left open (group B, n = 7). Results: 24 h after reperfusion, group A had higher levels of alanine aminotransferase (70 ± 12 IU/l vs. 51 ± 5.9 IU/l; p < 0.05), alanine aminotransferase per gram of liver remnant (0.41 ± 0.07 IU/l/g vs. 0.21 ± 0.05 IU/l/g; p < 0.05), prothrombin time (24.1 ± 2.4 s vs. 14.3 ± 2.9 s; p < 0.05), international normalized ratio (2.11 ± 0.15 vs. 1.29 ± 0.28; p < 0.05), hepatocyte necrosis scores and percentages of nuclei stained for proliferating cell nuclear antigen (52.57 ± 8.9% vs. 36.71 ± 6%; p < 0.05) compared to group B. Conclusions: Partial portal flow diversion appears to attenuate reperfusion injury in a porcine model of major hepatectomy.

© 2008 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 22, 2007
Accepted: October 02, 2007
Published online: February 26, 2008
Issue release date: May 2008

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 3

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

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2008, Vol.40, No. 4

May 2008

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