Neuropsychobiology

Biological Psychiatry

Serum Levels and Response to Amitriptyline in Depressed Out-Patients

Rowan P.R.a · Paykel E.S.b · Marks V.c · Mould G.d · Bhat A.b

Author affiliations

aThe Priory Hospital, Priory Lane, Roehampton, London; bDepartment of Psychiatry, St. George’s Hospital Medical School, London; cDepartment of Clinical Biochemistry, University of Surrey, Guildford, Surrey; dClinical Pharmacy Unit, Department of Clinical Biochemistry, St. Luke’s Hospital, Guildford, Surrey, UK

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Neuropsychobiology 1984;12:9–15

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry

Published online: February 19, 2008
Issue release date: 1984

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Serum levels of amitriptyline plus nortriptyline were measured by radioimmunoassay at 1 and 6 weeks in depressed out-patients treated with amitriptyline for 6 weeks. Serum concentrations at 6 weeks were higher in older patients. Serum levels showed no relationship to clinical response at 6 weeks, and a week inverse relationship with response at 2 weeks. Routine monitoring of serum levels appears to be of little value in depressed out-patients treated with amitriptyline.

© 1984 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry

Published online: February 19, 2008
Issue release date: 1984

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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