Neuropsychobiology
Biological Psychiatry
Platelet Monoamine Oxidase Activity and Plasma 3,4-Dihydroxy-phenylethylene Glycol Levels during the Menstrual CyclePoirier M.-F.a · Lôo H.a · Dennis T.b · Le Fur G.c · Scatton B.baService Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, Paris; bBiochemical Pharmacology Group, Synthélabo-LERS, Bagneux; cPharmuka Laboratory, Group Rhône Poulenc Santé, Gennevilliers, France
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Article / Publication Details
Published online: June 30, 2009
Issue release date: 1985
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)
For additional information: https://www.karger.com/NPS
Abstract
The influence of endocrine factors on monoamine oxidase activity (MAO) and on noradrenaline metabolism has been evaluated by measuring platelet MAO activity and plasma levels of 3,4-dihydroxyphenylethylene glycol (DOPEG), the major deaminated metabolite of noradrenaline, as well as serum levels of steroid hormones weekly in 9 young healthy women during one menstrual cycle. A decrease in platelet MAO activity (correlated with high serum estradiol levels) was observed during the ovulatory period. In contrast, plasma free or sulfoconjugated DOPEG remained unchanged throughout the menstrual cycle. These results indicate that the hormonal status should be taken into consideration in studies dealing with platelet MAO activity in depressed women.
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Article / Publication Details
Published online: June 30, 2009
Issue release date: 1985
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)
For additional information: https://www.karger.com/NPS
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