Neuropsychobiology

Biological Psychiatry

Plasma 3,4-Dihydroxyphenylethyleneglycol Levels in Depressed Patients with and without Abnormal Dexamethasone Suppression

Lôo H.a · Benkelfat C.a · Poirier M.-F.a · Gay C.a · Askienazy S.c · Dennis T.b · Scatton B.b

Author affiliations

aDepartment of Mental Health and Therapeutics and bDepartment of Nuclear Medicine, Sainte Anne Hospital, Paris-Cochin University Clinic, Paris; cBiochemical Pharmacology Group, Laboratoires d’Etudes et de Recherches Synthélabo, Bagneux, France

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Neuropsychobiology 1986;15:68–72

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry

Published online: February 19, 2008
Issue release date: 1986

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Escape from dexamethasone-induced suppression of plasma cortisol is an abnormality found in about half of patients with major depression. It has been hypothesized that this hyperactivity of the hypothalamo-pituitary-adrenal axis might be related to a central noradrenergic hypofunction. The present study was designed to test this hypothesis by measuring plasma 3,4-dihydroxyphenylethyleneglycol (DOPEG) levels (free and conjugated forms), an index of central noradrenergic activity, and by simultaneously carrying out a dexamethasone suppression test. Forty-five patients with a diagnosis of major depression (according to the DSM-III) were investigated. Plasma DOPEG levels (measured at 8 a.m.) were found to be similar in dexamethasone suppressor and nonsuppressor depressed patients. These results do not support the hypothesis that central noradrenergic hypoactivity underlies nonsuppression of dexamethasone in major depression.

© 1986 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry

Published online: February 19, 2008
Issue release date: 1986

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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