Neuropsychobiology
Biological Psychology/Pharmacopsychology
Can Anti-Panic Drugs Antagonise the Anxiety Produced in the Rat by Drugs Acting at the GABA-Benzodiazepine Receptor Complex?Pellow S. · File S.E.MRC Neuropharmacology Research Group, Department of Pharmacology, The School of Pharmacy, University of London, UK
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Article / Publication Details
Published online: February 20, 2008
Issue release date: 1987
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)
For additional information: https://www.karger.com/NPS
Abstract
The β-carboline FG 7142 and pentylenetetrazole, believed to act at different sites on the GABA-benzodiazepine receptor complex, have anxiogenic activity in the social interaction test in the rat. Two compounds that have anti-panic activity in man, the tricyclic antidepressant imipramine and the α2-adrenoceptor agonist clonidine, were used to try to antagonise the anxiogenic effects of the 2 drugs. Imipramine (5 and 15 mg/kg) was tested after 0 or 15 days pretreatment. In neither case was it able to reverse the anxiogenic effect of pentylenetetrazole (15 mg/kg). However, after chronic treatment the effects of FG 7142 were reversed. Imipramine itself had an anxiogenic action that was significant after acute treatment, and its effects were not additive with those of FG 7142 or pentylenetetrazole, suggestive of some mutual antagonism between acute imipramine and the 2 drugs. Similar mutual antagonism was obtained after acute treatment with clonidine (0.01 and 0.025 mg/kg).
© 1987 S. Karger AG, Basel
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Article / Publication Details
Published online: February 20, 2008
Issue release date: 1987
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)
For additional information: https://www.karger.com/NPS
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