Neuropsychobiology

Pharmacoelectroencephalography

Classification of Psychotropic Drugs by Rat EEG Analysis: The Anxiolytic Profile in Comparison to the Antidepressant and Neuroleptic Profile

Krijzer F.N.C.M. · van der Molen R.

Author affiliations

Duphar BV, Department of Pharmacology, Weesp, The Netherlands

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Neuropsychobiology 1987;18:51–56

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Article / Publication Details

First-Page Preview
Abstract of Pharmacoelectroencephalography

Published online: February 20, 2008
Issue release date: 1987

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Electroencephalograms were recorded from the parietal and frontal cortex of freely moving rats held in constant vigilance by placing them in a slowly turning drum. The effects of 5 clinically effective anxiolytics, buspirone, meprobamate, phenobarbital, chlordiazepoxide and diazepam, were studied after intraperitoneal injection of different doses. After on-line fast Fourier transformation of the EEG signal, the drug effects were quantified by an Analysis of Variance. This resulted in a t profile for each drug dosage. Averaging the t profiles of all dosages of a drug results in a ‘drug profile’. Averaging the drug profiles of the 5 anxiolytic drugs tested results in an ‘anxiolytic profile’. This profile is characterized by a power decrease from 8 to 11 Hz and above 70 Hz and a power increase from 20 to 60 Hz. The anxiolytic profile is compared with the formerly defined antidepressant and neuroleptic profiles and can be clearly distinguished from the latter two.

© 1987 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Pharmacoelectroencephalography

Published online: February 20, 2008
Issue release date: 1987

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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