Galanin Immunoreactivity in Human CSF: Studies in Eating Disorders and Alzheimer’s DiseaseBerrettini W.H.a · Kaye W.H.b · Sunderland T.a · May C.a · Gwirtsman H.E.d · Mellow A.a · Albright A.a
aNational Institute of Mental Health, Bethesda, Md.; bDepartment of Psychiatry, University of Pittsburgh, Pa.; cNational Institute on Aging, Bethesda, Md., and dDepartment of Psychiatry, University of California, Los Angeles, Calif., USA
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Galanin is a peptide which stimulates feeding behavior in animals and is found within those basal forebrain cholinergic neurons which degenerate in Alzheimer’s disease. Galanin was measured in cerebrospinal fluid (CSF) by radioimmunoassay. The nature of the immunoreactivity was characterized chromatographically as authentic galanin. CSF galanin levels were determined in subjects with Alzheimer’s disease, involutional depression, anorexia nervosa and bulimia. No differences between any diagnostic group and age and sex-matched controls were found.
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