Neuropsychobiology

Pharmacoelectroencephalography

Amplitudes of Auditory P300 in Remitted and Residual Schizophrenics: Correlations with Clinical Features

Strik W. · Dierks T. · Maurer K.

Author affiliations

Department of Psychiatry, University of Würzburg, FRG

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Neuropsychobiology 1993;27:54–60

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Article / Publication Details

First-Page Preview
Abstract of Pharmacoelectroencephalography

Published online: February 22, 2008
Issue release date: 1993

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

The parameters of auditory P300 were studied with reference-independent methods in a group of 18 remitted and residual schizophrenics, and in 18 age-and sex-matched controls. In the schizophrenic group, significant inverse correlations were found between P300 amplitudes and level of psychopathology assessed with the Scale for Assessment of Negative Symptoms and with the Brief Psychiatric Rating Scale. Clinical variables regarding social functioning and adaptation, assessed with the Schedule for Affective Disorders and Schizophrenia, and with axis V of DSM-III-R, correlated significantly with low amplitudes. The scalp locations of the maxima and minima of the P300 potentials had the tendency to be dislocated to the right in schizophrenics compared with controls. The results indicate low P300 amplitudes to be associated with pervasive cognitive impairment. Future studies will determine whether low P300 amplitudes have prognostic validity for course and outcome of schizophrenic disorders.

© 1993 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Pharmacoelectroencephalography

Published online: February 22, 2008
Issue release date: 1993

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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