Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.


Free Access

Testosterone and Blood Pressure Regulation

Kienitz T. · Quinkler M.

Author affiliations

Clinical Endocrinology, Department of Internal Medicine, Gastroenterology, Hepatology and Endocrinology, Charité Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany

Corresponding Author

Marcus Quinkler, MD

Clinical Endocrinology, Department of Internal Medicine, Gastroenterology, Hepatology and Endocrinology, Charité Campus Mitte

Charité Universitätsmedizin Berlin, Charitéplatz 1, DE–10117 Berlin (Germany)

Tel. +49 30 450 514 259, Fax +49 30 450 514 958, E-Mail marcus.quinkler@charite.de

Related Articles for ""

Kidney Blood Press Res 2008;31:71–79

Do you have an account?

Login Information

Contact Information

I have read the Karger Terms and Conditions and agree.


Background: There is substantial evidence that androgens may play a role in determining sex-specific blood pressure. Men are at higher risk for developing coronary heart disease or hypertension compared to premenopausal women. However, effects of androgens on the renal and cardiovascular system are complex. This review provides a critical overview of testosterone actions. Methods: We searched Pubmed library for experimental, animal and clinical studies, using the keywords ‘blood pressure’, ‘hypertension’, ‘testosterone’ and ‘androgens’. Results: While acute administration of testosterone seems to decrease vascular tone, the long-term net effect of androgens appears to be vasoconstriction via upregulation of thromboxane A2 expression, norepinephrine synthesis, angiotensin II expression, and endothelin-1 action. Furthermore, androgens cause cardiac hypertrophy, promote atherosclerosis, vascular remodelling and stimulate renal prohypertensive processes involving the renin-angiotensin-aldosterone system. Androgens seem to promote oxidative stress in the kidney and may also play a role in the differentiation of brain areas involved in blood pressure regulation. Conclusion: The effects of sex steroids on different parts of the renal-vascular system are complex and often contradictory. In sum, net effects of androgen action seem to be vasoconstriction, atherosclerosis and stimulation of the renin-angiotensin-aldosterone system. Therefore, androgens may determine blood pressure and the prevalence of cardiovascular disease.

© 2008 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Published online: March 04, 2008
Issue release date: April 2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 0

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.