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Review

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Testosterone and Blood Pressure Regulation

Kienitz T. · Quinkler M.

Author affiliations

Clinical Endocrinology, Department of Internal Medicine, Gastroenterology, Hepatology and Endocrinology, Charité Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany

Corresponding Author

Marcus Quinkler, MD

Clinical Endocrinology, Department of Internal Medicine, Gastroenterology, Hepatology and Endocrinology, Charité Campus Mitte

Charité Universitätsmedizin Berlin, Charitéplatz 1, DE–10117 Berlin (Germany)

Tel. +49 30 450 514 259, Fax +49 30 450 514 958, E-Mail marcus.quinkler@charite.de

Related Articles for ""

Kidney Blood Press Res 2008;31:71–79

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Abstract

Background: There is substantial evidence that androgens may play a role in determining sex-specific blood pressure. Men are at higher risk for developing coronary heart disease or hypertension compared to premenopausal women. However, effects of androgens on the renal and cardiovascular system are complex. This review provides a critical overview of testosterone actions. Methods: We searched Pubmed library for experimental, animal and clinical studies, using the keywords ‘blood pressure’, ‘hypertension’, ‘testosterone’ and ‘androgens’. Results: While acute administration of testosterone seems to decrease vascular tone, the long-term net effect of androgens appears to be vasoconstriction via upregulation of thromboxane A2 expression, norepinephrine synthesis, angiotensin II expression, and endothelin-1 action. Furthermore, androgens cause cardiac hypertrophy, promote atherosclerosis, vascular remodelling and stimulate renal prohypertensive processes involving the renin-angiotensin-aldosterone system. Androgens seem to promote oxidative stress in the kidney and may also play a role in the differentiation of brain areas involved in blood pressure regulation. Conclusion: The effects of sex steroids on different parts of the renal-vascular system are complex and often contradictory. In sum, net effects of androgen action seem to be vasoconstriction, atherosclerosis and stimulation of the renin-angiotensin-aldosterone system. Therefore, androgens may determine blood pressure and the prevalence of cardiovascular disease.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: March 04, 2008
Issue release date: April 2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 0

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR


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