Gynecologic and Obstetric Investigation

Original Article

Progesterone, Estrogen and Pregnancy Do Not Decrease Colon Myoelectric Activity in Rats: An in vivo Study

Speranzini L.B.M. · Lopasso P.P. · Laudanna A.A.

Author affiliations

Laboratory of Clinical Investigation LIM 07, Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil

Keywords: Colon myoelectric activityElectrodesProgesterone, estrogenPregnancy, ratsColon myoelectric activity in vivo

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Gynecol Obstet Invest 2008;66:53–58
https://doi.org/10.1159/000119643

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: July 06, 2006
Accepted: June 29, 2007
Published online: March 05, 2008
Issue release date: July 2008

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

Abstract

Background: Progesterone, estrogen and the hormonal complex of pregnancy have been responsible for some degree of colon hypomotility in human pregnancy. Objective: To find out if estrogen, progesterone and the hormonal complex of pregnancy decrease colon myoelectric activity. Methods: The study was performed in 37 healthy female rats in which electrodes were implanted on the serosa of the proximal ascendent, distal ascendent, transverse, and descendent colon. We analyzed the records of colon myoelectric activity in vivo in five groups: control, ovariectomized, ovariectomized and treated with estrogen, ovariectomized and treated with progesterone, and pregnant rats. Results: We found a great variation in myoelectric activity in all groups studied. The mean of electric activity did not show statistical difference among the five groups, but pregnant rats had a statistically significant higher duration of maximum electric activity in all distances from the cecocolon junction. Conclusion: Pregnant rats had a statistically higher duration of maximum electric activity. If we could transpose these results to humans, this increase in duration of colon myoelectric activity could explain, in part, the slight constipation that some pregnant women have.

© 2008 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: July 06, 2006
Accepted: June 29, 2007
Published online: March 05, 2008
Issue release date: July 2008

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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2008, Vol.66, No. 1

July 2008

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