American Journal of Nephrology

Original Report: Laboratory Investigation

Antibody Response to Influenza Immunization in Kidney Transplant Recipients Receiving either Azathioprine or Mycophenolate: A Controlled Trial

Keshtkar-Jahromi M.a · Argani H.b, c · Rahnavardi M.a · Mirchi E.c · Atabak S.c · Tara S.A.c · Gachkar L.a · Noori-Froothghe A.c · Mokhtari-Azad T.d

Author affiliations

aInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University (M.C.), Tehran, bClinical Laboratory Center, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, cClinical Research & Development Center, Nephrology Department, Shahid Modarres Medical Center, Shahid Beheshti University (M.C.), and dDepartment of Virology, School of Public Health, Tehran Medical University, Tehran, Iran

Keywords: InfluenzaVaccinationImmunizationKidney transplant recipientAntibody responseAzathioprineMycophenolate mofetil

Related Articles for ""
Am J Nephrol 2008;28:654–660
https://doi.org/10.1159/000119742

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Laboratory Investigation

Received: August 26, 2007
Accepted: January 17, 2008
Published online: March 06, 2008
Issue release date: June 2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

Abstract

Aims: We aimed to assess humoral immune response to the influenza vaccine in adult kidney transplant recipients (KTRs) subjected to two immunosuppressive regimens containing either mycophenolate mofetil (MMF) or azathioprine (Aza). Methods: 40 eligible KTRs (24 treated with Aza [KTRs-Aza] and 16 treated with MMF [KTRs-MMF]) and 40 matched healthy controls (HCs) were administered the trivalent 2006–2007 anti-influenza vaccine. Antibody (Ab) titers were measured before (pre-vacc) and 1 month after (post-vacc) vaccination. The proportion of protective Ab titers (i.e. ≧1:40), the serological response (i.e. ≧4-fold rise in titers) rates, and the magnitudes of change in titers were evaluated. Results: KTRs and HCs were similar in serologic responses, magnitudes of change in Ab titers, and proportions of acquired protective titers against all antigens. Whereas KTRs-MMF and KTRs-Aza were identical in magnitude of rise in titers as well as in serologic responses, KTRs-MMF did poorer in developing post-vacc-protective titers against A/H1N1 (p < 0.05). The function of the transplanted kidney has not deteriorated after vaccination. Conclusions: Anti-influenza vaccination was safe in KTRs and evoked Ab responses comparable to those of HCs. KTRs-MMF and KTRs-Aza responded almost equally to the vaccine. Annual anti-influenza vaccination can be recommended to all stable KTRs.

© 2008 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Report: Laboratory Investigation

Received: August 26, 2007
Accepted: January 17, 2008
Published online: March 06, 2008
Issue release date: June 2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

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2008, Vol.28, No. 4

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