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Fungal Enzymes for Environmental Purposes, a Molecular Biology Challenge

Ayala M.a · Pickard M.A.b · Vazquez-Duhalt R.a

Author affiliations

aInstituto de Biotecnología, Universidad Nacional Autonoma de Mexico (UNAM), Cuernavaca, Mexico; bUniversity of Alberta, Edmonton, Alta., Canada

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J Mol Microbiol Biotechnol 2008;15:172–180

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: July 28, 2008
Issue release date: August 2008

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 4

ISSN: 1464-1801 (Print)
eISSN: 1660-2412 (Online)

For additional information: https://www.karger.com/MMB

Abstract

In their capacity to transform xenobiotics and polluting compounds, fungal peroxidases and their use in the environmental field have a recognized and important potential. However, both fundamental and practical issues, such as enzyme stability and availability, have delayed the development of industrial applications. Three main protein engineering challenges have been identified: (1) Enhancement of operational stability, specifically hydrogen peroxide stability in the case of fungal peroxidases. (2) Increase of the enzyme redox potential in order to widen the substrate range. (3) Development of heterologous expression and industrial production. The bottlenecks, advances and strategies that have been proven successful are discussed.

© 2008 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: July 28, 2008
Issue release date: August 2008

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 4

ISSN: 1464-1801 (Print)
eISSN: 1660-2412 (Online)

For additional information: https://www.karger.com/MMB


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