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Basic Science Investigations

Prevention of Mast Cell Degranulation by Disodium Cromoglycate Attenuates the Development of Hypoxic Pulmonary Hypertension in Rats Exposed to Chronic Hypoxia

Baňasová A.a, e · Maxová H.b, e · Hampl V.a, e · Vízek M.b, e · Povýšilová V.c, e · Novotná J.d, e · Vajnerová O.a, e · Hniličková O.a, e · Herget J.a, e

Author affiliations

Departments of aPhysiology, bPathological Physiology, cPathology and Molecular Medicine, and dMedical Chemistry and Biochemistry, Charles University Second Medical School Prague, and eCardiovascular Research Centre, Prague, Czech Republic

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Respiration 2008;76:102–107

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Article / Publication Details

First-Page Preview
Abstract of Basic Science Investigations

Received: July 30, 2007
Accepted: January 09, 2008
Published online: March 18, 2008
Issue release date: June 2008

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES

Abstract

Background: Chronic hypoxia induces lung vascular remodeling, which results in pulmonary hypertension. Vascular remodeling is associated with collagenolysis and activation of matrix metalloproteinases (MMPs). One of the possible sources of MMPs in hypoxic lung are mast cells. Objective: The role of lung mast cell collagenolytic activity in hypoxic pulmonary hypertension was tested by the inhibitor of mast cell degranulation disodium cromoglycate (DSCG). Methods: Rats were treated with DSCG in an early or later phase of isobaric hypoxia. Control groups were exposed to hypoxia only or to normoxia. Lung hemodynamics, muscularization and collagen metabolism in the walls of peripheral pulmonary vessels in the lungs were measured. Results: DSCG applied at an early phase of exposure to hypoxia reduced the development of pulmonary hypertension, inhibited muscularization in peripheral pulmonary arteries and decreased the amount of collagen cleavage fragments in prealveolar vessels. Conclusions: Mast cell degranulation plays a role in the initiation of hypoxic pulmonary vascular remodeling.

© 2008 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Basic Science Investigations

Received: July 30, 2007
Accepted: January 09, 2008
Published online: March 18, 2008
Issue release date: June 2008

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES


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