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Original Paper

Gelatinous Transformation of Bone Marrow in Chronic Myeloid Leukemia during Treatment with Imatinib Mesylate: A Disease or a Drug Effect?

Ram R.a, c · Gafter-Gvili A.a, c · Okon E.b, c · Pazgal I.a, c · Shpilberg O.a, c · Raanani P.a, c

Author affiliations

aInstitutes of Hematology and bPathology, Rabin Medical Center, Beilinson Hospital, Petah Tikva, and cSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Related Articles for ""

Acta Haematol 2008;119:104–107

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 17, 2008
Accepted: January 21, 2008
Published online: March 27, 2008
Issue release date: April 2008

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA

Abstract

Gelatinous marrow transformation (GMT) is an unusual pathological manifestation of progressive malignant diseases and severe malnutrition states. GMT has been associated with various accelerated hematological malignancies, but has never been described in patients with chronic myelogenous leukemia (CML) treated with imatinib mesylate (IM), a novel tyrosine kinase inhibitor. Herein we report 2 patients with stable chronic phase CML who developed GMT during the course of treatment with IM. A comprehensive review of the relevant published data, several possible mechanisms and therapeutic alternatives are suggested.

© 2008 S. Karger AG, Basel


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 17, 2008
Accepted: January 21, 2008
Published online: March 27, 2008
Issue release date: April 2008

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA


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