Neuroendocrinology
Effect of Stimulation of the Medulla Oblongata on Renin Secretion in DogsPasso S.S. · Assaykeen T.A. · Otsuka K. · Wise B.L. · Goldfien A. · Ganong W.F.Departments of Physiology, Medicine and Obstetrics and Gynecology and the Cardiovascular Research Institute, University of California, School of Medicine, San Francisco Medical Center, San Francisco, California, and Departments of Surgery (Urology) and Pharmacology, Stanford University School of Medicine, Stanford, California, USA
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Article / Publication Details
Received: December 01, 1969
Accepted: May 15, 1970
Published online: March 19, 2008
Issue release date: 1971
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
Electrodes were implanted in dogs in the dorsal portion of the medulla oblongata near the obex. A week or more later, the electrodes were stimulated while changes in plasma renin activity, plasma epinephrine and norepinephrine, and blood pressure were monitored. Stimulation of 20 points in 16 dogs produced clear-cut increases in plasma renin activity. In almost all instances, these increases were associated with marked increases in blood pressure. There was also a small increase in circulating epinephrine without a significant change in plasma norepinephrine. Stimulation of the medulla 4 h after renal denervation was not associated with any increase in plasma renin activity even though the pressor response was comparable to that before denervation. The response was also absent in dogs stimulated two week after renal denervation. The data show that renin secretion can be increased in association with marked increases in blood pressure. They also show that the increase produced by stimulation of the medulla oblongata is mediated via the renal nerves.
© 1971 S. Karger AG, Basel
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Article / Publication Details
Received: December 01, 1969
Accepted: May 15, 1970
Published online: March 19, 2008
Issue release date: 1971
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
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