Effect of Monosodium Glutamate on Some Endocrine FunctionsRedding T.W. · Schally A.V. · Arimura A. · Wakabayashi I.
Endocrine and Polypeptide Laboratory, Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Neonatal female and male rats of the Sprague-Dawley strain were injected subcutaneously with a daily dose of MSG (2.2–4.2 mg/g body wt.) beginning on the 2nd day of life. The rats were autopsied at 40 and 110 days of age. At 40 days of age, the body weight and nasoanal lengths were significantly reduced in the MSG-treated rats. At 110 days, the body lengths of MSG-treated rats were approximately 10–12% shorter than those of control rats, and calculation of the ‘Lee’ index indicated a significant increase in carcass fat. Food consumption studies, carried out at 75 days of age, showed a significant hypophagia in some MSG-treated rats. Upon autopsy at 40 days of age, the absolute weights of the thyroid and adrenal glands of both sexes were significantly decreased from those of control rats; but when corrected for body weight, these differences were marginal. At 110 days, the absolute weights of the adrenal and thyroid glands of both sexes were significantly reduced from their respective control levels. Gonadal weights of MSG-treated rats were significantly reduced at 40 and 110 days of age. Size and weight of the anterior pituitary glands of both male and female MSG-treated rats were significantly reduced from control values. There was a marked decrease in growth hormone and luteinizing hormone content in the anterior pituitaries of male and female MSG-treated rats at 40 days. However, thyrotropin content of the anterior pituitary of MSG-treated male rats did not show any significant change from control levels at 40 days of age.
© 1971 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.