Neuroendocrinology
Central Effects of Angiotensin II in Water and Saline Loaded RatsHoffman W.E. · Weet J.F. · Phillips M.I. · Schmid P.G.Department of Medical Physiology, Texas A&M University, College Station, Tex., and Cardiovascular Division, Department of Internal Medicine and Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa
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Article / Publication Details
Received: May 16, 1978
Accepted: September 28, 1978
Published online: March 26, 2008
Issue release date: 1979
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
In unanesthetized water-loaded rats, intracerebroventricular (IVT) angiotensin II (All) injections produce centrally mediated pressor effects and antidiuresis. Experiments were performed to evaluate the role of antidiuretic hormone (ADH) release versus neurogenic mechanisms in the antidiuretic responses to central AIL Median eminence lesions used to block ADH release abolish antidiuretic effects but only attenuated pressor responses to IVT All infusions. Pretreatment with an intravenous infusion of ADH antibody had a similar effect. Central administration of All in water and saline-loaded rats produced no change in effective renal plasma flow or glomerular filtration rate. Natriuretic and kaliuretic responses to IVT All injections were similar to those observed to intravenous ADH infusions. These data are consistent with the suggestion that antidiuresis and osmotic excretion observed after IVT All injections in the rats are the result of ADH release, and that neurogenic mechanisms play a major role in the blood pressure but not in the antidiuretic responses.
© 1979 S. Karger AG, Basel
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Article / Publication Details
Received: May 16, 1978
Accepted: September 28, 1978
Published online: March 26, 2008
Issue release date: 1979
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
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