Neuroendocrinology
Original Paper
Dose-Response Relation of CSF Sodium and Renal Sodium Excretion, and Its Absence in Homozygous Brattleboro RatsMouw D.R. · Vander A.J. · Landis C. · Kutschinski S. · Mathias N. · Zimmerman D.Department of Physiology, University of Michigan Medical School, Ann Arbor, Mich.
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Article / Publication Details
Received: April 10, 1979
Accepted: August 10, 1979
Published online: March 26, 2008
Issue release date: 1980
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
Constant intraventricular infusion (3.3–6.6 μl/min) of artificial cerebrospinal fluid with sodium concentrations of 100, 150, 200, 250, 300, and 350 mM produced a linear dose-related change in renal sodium excretion in conscious, unrestrained Sprague-Dawley rats. The periventricular receptors stimulated were able to evoke substantial changes in body sodium balance; the 350 mM Na CSF produced an estimated 14% deficit in the content of Na in the extracellular fluid over a 5-hour infusion period. This is the first demonstration of such a dose-response relation over a wide range of CSF Na concentration (above and below normal) in conscious animals. Both the dose-response relation, and the magnitude of the effects, suggests an important physiologic role for this control mechanism. The natriuresis in response to 300 mM sodium infusion was identical in Long-Evans Brattleboro rats heterozygous for diabetes inspidus (Dl), and in Sprague-Dawley rats, but was completely absent in homozygous animals. Although the experimental methods (conscious unrestrained rats) precluded simultaneous evaluation of efferent pathways other than antidiuretic hormone (ADH), the evidence from the DI rats suggests that ADH may be the efferent pathway for the response.
© 1980 S. Karger AG, Basel
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Article / Publication Details
Received: April 10, 1979
Accepted: August 10, 1979
Published online: March 26, 2008
Issue release date: 1980
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
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