Neuroendocrinology
Original Paper
Effect of Chronic Intracerebroventricular Angiotensin II Infusion on Vasopressin Release in RatsSterling G.H. · Chee O. · Riggs R.V. · Keil L.C.Biomedical Research Division, National Aeronautics and Space Administration, Ames Research Center, Moffett Field, Calif.
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Article / Publication Details
Received: September 24, 1979
Accepted: February 12, 1980
Published online: March 26, 2008
Issue release date: 1980
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
Angiotensin II (AII) was infused into the lateral cerebral ventricle of rats given water, isotonic saline, or hypertonic saline ad libitum, or 40 ml water/day. Fluid intake, change in body weight, plasma [Na+], and plasma and pituitary arginine vasopressin (AVP) levels were measured. Isotonic saline or All (1 µg/µl saline) was infused at 1 µl/h for 5 days using osmotic minipumps. All increased fluid intake of rats given isotonic saline to drink; they consumed an average of 269 ± 25 ml/day on day 5. All infusions in rats given water or isotonic saline to drink decreased plasma [Na+] with no changes in plasma or pituitary AVP. However, in rats given hypertonic saline, plasma [Na+] remained at control levels while plasma AVP increased. In water-restricted rats, the effects of AII were intermediate: a small decrease in plasma [Na+] and a small increase in plasma AVP. From these results, it is suggested that although acute All administration elicits AVP release, this effect diminishes during chronic ATI infusion, coincident with reduced plasma [Na+].
© 1980 S. Karger AG, Basel
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Article / Publication Details
Received: September 24, 1979
Accepted: February 12, 1980
Published online: March 26, 2008
Issue release date: 1980
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
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