Neuroendocrinology

Original Paper

Effect of Chronic Intracerebroventricular Angiotensin II Infusion on Vasopressin Release in Rats

Sterling G.H. · Chee O. · Riggs R.V. · Keil L.C.

Author affiliations

Biomedical Research Division, National Aeronautics and Space Administration, Ames Research Center, Moffett Field, Calif.

Related Articles for ""

Neuroendocrinology 1980;31:182–188

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 24, 1979
Accepted: February 12, 1980
Published online: March 26, 2008
Issue release date: 1980

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN

Abstract

Angiotensin II (AII) was infused into the lateral cerebral ventricle of rats given water, isotonic saline, or hypertonic saline ad libitum, or 40 ml water/day. Fluid intake, change in body weight, plasma [Na+], and plasma and pituitary arginine vasopressin (AVP) levels were measured. Isotonic saline or All (1 µg/µl saline) was infused at 1 µl/h for 5 days using osmotic minipumps. All increased fluid intake of rats given isotonic saline to drink; they consumed an average of 269 ± 25 ml/day on day 5. All infusions in rats given water or isotonic saline to drink decreased plasma [Na+] with no changes in plasma or pituitary AVP. However, in rats given hypertonic saline, plasma [Na+] remained at control levels while plasma AVP increased. In water-restricted rats, the effects of AII were intermediate: a small decrease in plasma [Na+] and a small increase in plasma AVP. From these results, it is suggested that although acute All administration elicits AVP release, this effect diminishes during chronic ATI infusion, coincident with reduced plasma [Na+].

© 1980 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 24, 1979
Accepted: February 12, 1980
Published online: March 26, 2008
Issue release date: 1980

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN


Copyright / Drug Dosage / Disclaimer

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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