Neuroendocrinology
Original Papers
Adrenal Steroid Inhibition of the Vasopressin-Neurophysin Neurosecretory System to the Median Eminence of the RatDifferential Effects of Corticosterone and Deoxycorticosterone Administration after Adrenalectomy
Silverman A.J. · Hoffman D. · Gadde C.A. · Krey L.C. · Zimmermann E.A.
Departments of Anatomy and Neurology, Columbia University, College of Physicians and Surgeons and Rockefeller University, New York, N.Y., USA
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Article / Publication Details
Received: June 19, 1980
Accepted: September 04, 1980
Published online: March 26, 2008
Issue release date: 1981
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
Neurophysin and vasopressin-containing terminals in the zona externa of the median eminence (ZE) show a large increase in immunoreactive peptide following adrenalectomy which can be prevented by dexamethazone replacement therapy. The present study was undertaken to determine the effectiveness of a glucocorticoid (corticosterone; CS) and a mineralocorticoid (deoxycorticosterone; DOC) in exerting negative feedback on this system. Animals were adrenalectomized and implanted with various sized pellets of either steroid or cholesterol. The amount of neurophysin-immunoreactivity in the ZE 2 weeks after adrenalectomy was estimated on a zero to four rank scale independently by three observers. The data were analyzed by the X2 statistic. Low doses of CS (50 mg) reduced the amount of staining in comparison to cholesterol-replaced animals by approximately 50%. The ZE of animals receiving higher doses (100–200 mg) were identical to those of intact animals. DOC, however, at the 50 or 100 mg level produced only a slight inhibition of the response to adrenalectomy. Larger pellets (150–200 mg) did not result in a level of ZE staining as low as for intact animals. These findings suggest that the vasopressin neurosecretory system to the ZE is regulated by glucocorticoids.
© 1981 S. Karger AG, Basel
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Article / Publication Details
Received: June 19, 1980
Accepted: September 04, 1980
Published online: March 26, 2008
Issue release date: 1981
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
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