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Regular Article

Psychiatric and Medical Effects of Anabolic-Androgenic Steroid Use in Women

Gruber A.J. · Pope Jr. H.G.

Author affiliations

Biological Psychiatry Laboratory, McLean Hospital, Belmont, Mass., and the Department of Psychiatry, Harvard Medical School, Boston, Mass., USA

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Psychother Psychosom 2000;69:19–26

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Article / Publication Details

First-Page Preview
Abstract of Regular Article

Published online: December 10, 1999
Issue release date: January – February

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 5

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: https://www.karger.com/PPS

Abstract

Background: Although numerous studies have documented the psychiatric and physiological effects of anabolic-androgenic steroids (AAS) in males, virtually no studies have investigated the effects of illicit AAS use in women. Methods: We performed psychiatric and medical evaluations of 75 dedicated women athletes, recruited by advertisement primarily from gymnasiums in the Boston, Mass., area. Results: Twenty-five (33%) of the women reported current or past AAS use. Users were more muscular than nonusers and reported use of many other ‘ergogenic’ (performance-enhancing) drugs in addition to AAS. Some described a frank syndrome of ergogenic polysubstance dependence, often with significant morbidity. Fourteen (56%) of the users reported hypomanic symptoms during AAS use and 10 (40%) reported depressive symptoms during AAS withdrawal, but none met full DSM-IV criteria for a hypomanic or major depressive episode. Nineteen (76%) users reported at least one adverse medical effect associated with AAS use. Perhaps the most interesting findings were several unusual psychiatric syndromes reported by both the AAS users and nonusers. These included rigid dietary practices (which we have termed ‘eating disorder, bodybuilder type’), nontraditional gender roles and chronic dissatisfaction and preoccupation with their physiques (a syndrome which we have termed ‘muscle dysmorphia’). Conclusions: Dedicated women athletes exhibit not only AAS abuse, but use of many other ergogenic drugs, sometimes associated with significant morbidity. In addition, these athletes frequently display several psychiatric syndromes which have not previously been well described.

© 2000 S. Karger AG, Basel


References

  1. Forbes GB, Porta CR, Herr BE, Griggs RC: Sequence of changes in body composition induced by testosterone and reversal of changes after drug is stopped. JAMA 1992;267:397–399.
  2. Bagatell CJ, Heiman JR, Matsumoto AM, Rivier JE, Bremner WJ: Metabolic and behavioral effects of high-dose, exogenous testosterone in healthy men. J Clin Endocrinol Metab 1994;79:561–567.
  3. Bhasin S, Storer TW, Berman N, Callegari C, Clevenger B, Phillips J, Bunnell TJ, Tricker R, Shirazi A, Casaburi R: The effect of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 1996;335:1–7.
  4. Pope HG Jr, Katz DL: Psychiatric and medical effects of anabolic-androgenic steroid use. Arch Gen Psychiatry 1994;51:375–382.
  5. Brower KJ, Blow FC, Young JP, Hill EM: Symptoms and correlates of anabolic-androgenic steroid dependence. Br J Addict 1991;86:759–768.
  6. Rubinow DR, Schmidt PJ: Androgens, brain, and behavior. Am J Psychiatry 1996;153:974–984.
  7. Pope HG Jr, Katz DL: Psychiatric effects of exogenous anabolic-androgenic steroids; in Wolkowitz OM, Rothschild AJ (eds): Psychoneuroendocrinology for the clinician. Washington, American Psychiatric Press, in press.
  8. Yesalis CE, Kennedy NJ, Kopstein AN, Bahrke MS: Anabolic-androgenic steroid use in the United States. JAMA 1993;270:1217–1221.
  9. Johnson MD, Jay MS, Shoup B, Rickert VI: Anabolic steroid use in adolescent males. Pediatrics 1989;83:921–924.
    External Resources
  10. Johnston L, Bachman J, O’Malley P: Monitoring the Future: Continuing Study of the Lifestyles and Values of Youth. Ann Arbor, University of Michigan Institute for Social Research, 1990–1991.
  11. Ross J, Winters F, Hartmann K, et al: 1988–89 Survey of Substance Abuse among Maryland adolescents. Baltimore, Maryland Department of Health and Mental Hygiene, Alcohol and Drug Abuse Administration, 1989.
  12. DuRant RH, Rickert VI, Ashworth CS, Newman C, Stevens G: Use of multiple drugs among adolescents who abuse anabolic steroids. N Engl J Med 1993;328:922–926.
  13. Terney R, McLain L: The use of anabolic steroids in high school students. Am J Dis Child 1990;144:99–103.
  14. Radokovich J, Broderick P, Pickell G: Rates of anabolic-androgenic steroid abuse among students in junior high school J Am Board Fam Pract 1993;6:341–345.
  15. Yesalis LE, Barsukiewicz CK, Kopstein AN, Bahrke MS: Trends in anabolic-androgenic steroid use among adolescents. Arch Pediatr Adolesc Med 1997;151:1197–1206.
    External Resources
  16. Strauss R, Liggett M, Lanese R: Anabolic steroid use and perceived effects in ten weight-trimmed women athletes. JAMA 1985;253:2871–2873.
  17. Moffa HR, Wallace M, Sady S: Effects of anabolic steroids on lipoprotein profiles of female weight lifters. Physician Sportsmed 1990;18:106–110.
  18. Malarkey WB, Strauss RH, Leizman DJ, Liggett M, Demers LM: Endocrine effects in female weight lifters who self-administer testosterone and anabolic steroids. Am J Obstet Gynecol 1991;165:1385–1390.
  19. First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). New York, New York State Psychiatric Institute, 1989.
  20. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 3 (DSM- IV). Washington, American Psychiatric Association, 1987.
  21. Pope HG Jr, Gruber AJ, Choi PY, Olivardia R, Phillips KA: Muscle dysmorphia: An under-recognized form of body dysmorphic disorder. Psychosomatics 1997;38:548–557.
  22. Jackson AS, Pollock ML, Ward A: Generalized equations for predicting body density of women. Med Sci Sports Exerc 1980;12:175–182.
  23. Kouri EM, Pope HG Jr, Katz DL, Oliva PS: Fat-free mass index in users and non-users of anabolic-androgenic steroids. Clin J Sport Med 1995;5:223–228.
  24. Bjorntorp P: The android woman – A risky condition. J Intern Med 1996;239:105–110.
  25. Fava GA, Freyberger HJ, Bech P, Christodoulou G, Sensky T, Theorell T, Wise TN: Diagnostic criteria for use in psychosomatic research. Psychother Psychosom 1995;63:1–8.
  26. Gruber AJ, Pope HG Jr: Ephedrine abuse among 36 female weightlifters. Am J Addict 1998;7:256–261.
  27. Wines JD Jr, Gruber AJ, Pope HG Jr, Lukas SE: Nalbuphine hydrochloride dependence in anabolic steroid users. Am J Addict, in press.
  28. Pope HG Jr, Kouri EM, Hudson JI: The effects of supraphysiologic doses of testosterone on mood and aggression in men. Arch Gen Psychiatry, in press.
  29. Patten SB, Love EJ: Drug-induced depression. Psychother Psychosom 1997;66:63–73.
  30. Ling MHM, Perry PJ, Tsuang MT: Side effects of corticosteroid therapy: Psychiatric aspects. Arch Gen Psychiatry 1981;38:471–477.

Article / Publication Details

First-Page Preview
Abstract of Regular Article

Published online: December 10, 1999
Issue release date: January – February

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 5

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: https://www.karger.com/PPS


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