Neuroendocrinology
Original Paper
Differentiation of the Sexually Dimorphic Nucleus in the Preoptic Area of the Rat Brain Is Inhibited by Postnatal Treatment with an Estrogen AntagonistDöhler K.D.a · Srivastava S.S.a · Shryne J.E.b · Jarzab B.a · Sipos A.a,c · Gorski R.A.baDepartment of Clinical Endocrinology, University of Hannover Medical School, Hannover, West Germany; bDepartment of Anatomy and Laboratory of Neuroendocrinology of the Brain Research Institute, UCLA School of Medicine, Los Angeles, Calif., USA; cLaboratory of Clinical Biochemistry, Chinoin, Budapest, Hungary
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Article / Publication Details
Received: July 21, 1983
Accepted: September 20, 1983
Published online: March 28, 2008
Issue release date: 1984
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is several fold larger in adult male rats than in adult females. This sex difference in brain structure was previously shown to develop under the influence of androgenic and estrogenic hormones during the perinatal period. We here report that treatment of newborn male and female rats with the estrogen antagonist tamoxifen significantly inhibited growth and differentiation of the SDN-POA in both sexes and it resulted in permanent anovulatory sterility in females. The findings suggest (a) that testicular androgens exert their growth promoting activity on SDN-POA development only after being converted into estrogens, and (b) that also in the female rat structural and possibly functional brain differentiation is under estrogenic control.
© 1984 S. Karger AG, Basel
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Article / Publication Details
Received: July 21, 1983
Accepted: September 20, 1983
Published online: March 28, 2008
Issue release date: 1984
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Copyright / Drug Dosage / Disclaimer
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