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Original Paper

New Data on the Intraindividual Variation of Cystatin C

Delanaye P.a · Cavalier E.b · Depas G.c · Chapelle J.-P.b · Krzesinski J.-M.a

Author affiliations

Departments of aNephrology, bClinical Chemistry, and cNuclear Medicine, University of Liege, CHU Sart Tilman, Liege, Belgium

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Nephron Clin Pract 2008;108:c246

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 12, 2007
Accepted: March 01, 2008
Published online: April 09, 2008
Issue release date: May 2008

Number of Print Pages: 1
Number of Figures: 0
Number of Tables: 1


eISSN: 1660-2110 (Online)

For additional information: https://www.karger.com/NEC

Abstract

Background: Cystatin C is a new interesting marker of glomerular filtration rate (GFR). However, data regarding its biological variance are scarce and conflicting. The ability of cystatin C to longitudinally follow renal function in patients therefore remains questionable. Methods: 12 healthy subjects (6 men and 6 women) were included in the final statistical analysis. Serum creatinine, plasma cystatin C and GFR were measured twice after a 1-week interval on the same day, at the same time, and under the same preanalytical and analytical conditions. GFR was measured with an iohexol method. Serum creatinine was measured with a compensated Jaffé and an enzymatic method. Plasma cystatin C was measured by a particle-enhanced immunonephelometric method. Analytical (CVA) and within-subject (CVI) variances were classically calculated. Results: CVA for creatinine (Jaffé and enzymatic methods) and cystatin C was 2.5, 0.97 and 1.29%, respectively. CVI was 5.8, 5 and 4.5% for the Jaffé creatinine, enzymatic creatinine and cystatin C determinations, respectively. Conclusion: Our study confirms that intraindividual variation of cystatin C and creatinine are similar. Therefore, from a biological point of view, cystatin C seems as accurate as creatinine for the longitudinal follow-up of renal function in daily clinical practice.

© 2008 S. Karger AG, Basel


References

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 12, 2007
Accepted: March 01, 2008
Published online: April 09, 2008
Issue release date: May 2008

Number of Print Pages: 1
Number of Figures: 0
Number of Tables: 1


eISSN: 1660-2110 (Online)

For additional information: https://www.karger.com/NEC


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