Neuroendocrinology

Original Paper

Effects of Corticotropin-Releasing Factor and Growth Hormone-Releasing Factor on Sleep and Activity in Rats

Ehlers C.L. · Reed T.K. · Henriksen S.J.

Author affiliations

Division of Neuroscience and Endocrinology, Scripps Clinic and Research Foundation, La Jolla, Calif., USA

Related Articles for ""

Neuroendocrinology 1986;42:467–474

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 11, 1985
Accepted: June 17, 1985
Published online: April 01, 2008
Issue release date: 1986

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN

Abstract

The effects of corticotropin-releasing factor (CRF) and growth hormone-releasing factor (GRF) on electroencephalograpic (EEG) and behavioral signs of sleep and wakefulness following intracerebroventricular (ICV) administration was investigated in adult male rats. Visual scoring of EEG records as well as spectral analysis revealed that CRF (0.0015–0.015 nmol) produced decreases in slow wave sleep concomitant with significant decreases in spectral power in lower frequencies (1–6 Hz) and increases in high frequencies (32–64 Hz). In contrast, GRF (2.0 nmol) produced increased EEG and behavioral signs of slow wave sleep associated with significant increases in spectral power in the low frequencies (1–2 Hz) and decreases in high frequencies (32–64 Hz). ICV administration of GRF was also found to produce decreases in locomotion when administered during the active part of the rats’ circadian cycle. These EEG and behavioral findings seen following CRF and GRF are consistent with the behaviors frequently correlated with the known circadian timing of the release of corticosteroids and growth hormone during the sleep-waking cycle in rat and human.

© 1986 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 11, 1985
Accepted: June 17, 1985
Published online: April 01, 2008
Issue release date: 1986

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN


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