Neuroendocrinology
Original Paper
Effect of the Opioid Peptide Beta-Endorphin on the in vivo Release of Vasopressin in Rats under Various Conditionsten Haaf J.A. · van Wimersma Greidanus T.B. · Maigret C. · De Wied D.Rudolf Magnus Institute for Pharmacology, State University of Utrecht, The Netherlands
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Article / Publication Details
Received: November 20, 1985
Accepted: March 31, 1986
Published online: April 01, 2008
Issue release date: 1986
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
β-Endorphin (βE) exerts a strong inhibitory action on plasma vasopressin (VP) of rats, after intracerebroventricular, but not after subcutaneous injection of the drug. This effect is time- and dose-dependent. Also in the water-deprived rat, this treatment leads to a strong decrease of plasma VP levels. When rats treated with histamine (HIS) intracerebroventricularly to stimulate VP levels are injected with βE to HIS treatment, βE partially prevents the increase of plasma VP levels. Naloxone subcutaneously administered, antagonizes the effect of βE in all the situations we investigated. Opioid receptors, located in the brain as well as in the pituitary, are possibly involved in these processes.
© 1986 S. Karger AG, Basel
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Article / Publication Details
Received: November 20, 1985
Accepted: March 31, 1986
Published online: April 01, 2008
Issue release date: 1986
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
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