Neuroendocrinology

Original Paper

Effect of Chronic Morphine on Plasma and Brain Beta Endorphin and Methionine Enkephalin in Pregnant Rats and in Their Fetuses or Newborn

Bianchi M. · Marini A. · Sacerdote P. · Cocco E. · Brini A. · Panerai A.E.

Author affiliations

Department of Pharmacology Neonatal Service, School of Medicine, University of Milan, Italy

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Neuroendocrinology 1988;47:89–94

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 10, 1986
Accepted: April 22, 1987
Published online: April 02, 2008
Issue release date: 1988

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN

Abstract

Normal or pregnant rats were treated orally for 21 days or throughout pregnancy with water or increasing doses of morphine and killed on days 7, 14, and 21 of pregnancy and 1 day post partum. At these time intervals, plasma, pituitary, and hypothalamic concentrations of β-endorphin and methionine enkephaline were measured in normal and pregnant rats. Moreover, pituitary and hypothalamic concentrations of the two peptides were also measured in fetuses and newborn. Plasma β-endorphin and methionine enkephalin increased significantly during pregnancy without any specific effect of morphine. Pituitary concentrations of β-endorphin were not modified either by pregnancy or morphine treatment, while methionine enkephalin concentrations increased on days 7 and 11 of pregnancy, in both water- and morphine-treated rats. The pattern of the two peptides in the hypothalamus is completely superimposable to the one present in the pituitary with the exception of an increase of β-endorphin on day 21 of pregnancy, which is more evident in control animals. Consistently with our observations in human newborn and the neurological dysfunctions we observed in them, the concentrations of both the peptides are significantly increased in the hypothalamus of fetuses and newborn of morphine-treated mothers, while in the pituitary only β-endorphin concentrations are increased.

© 1988 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 10, 1986
Accepted: April 22, 1987
Published online: April 02, 2008
Issue release date: 1988

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN


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